(2R,3R)-2-(2,4-Difluorophenyl)-3-(2-tetrahydropyranyloxy)-1,2-butanediol

Base Information

• Chemical Name: (2R,3R)-2-(2,4-Difluorophenyl)-3-(2-tetrahydropyranyloxy)-1,2-butanediol
• CAS No.: 126918-19-2
• Molecular Formula: C₁₅H₂₀F₂O₄
• Molecular Weight: 302.318

Synonyms:(2R,3R)-2-(2,4-Difluorophenyl)-3-(2-tetrahydropyranyloxy)-1,2-butanediol

Chemical Property of (2R,3R)-2-(2,4-Difluorophenyl)-3-(2-tetrahydropyranyloxy)-1,2-butanediol

Chemical Property:

Purity/Quality:

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Technology Process of (2R,3R)-2-(2,4-Difluorophenyl)-3-(2-tetrahydropyranyloxy)-1,2-butanediol

There total 14 articles about (2R,3R)-2-(2,4-Difluorophenyl)-3-(2-tetrahydropyranyloxy)-1,2-butanediol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

(2R,3S)-2-(2,4-Difluoro-phenyl)-1-(isopropoxy-dimethyl-silanyl)-3-(tetrahydro-pyran-2-yloxy)-butan-2-ol (126918-18-1,132563-66-7,138457-40-6) → (2S,3S)-2-(2,4-Difluoro-phenyl)-3-(tetrahydro-pyran-2-yloxy)-butane-1,2-diol (126918-19-2,132563-82-7)

Guidance literature:

With dihydrogen peroxide; sodium hydrogencarbonate; In tetrahydrofuran; methanol; at 70 ℃;

DOI:10.1248/cpb.39.2241

Reference yield: 35.0%

(2S,3R)-2-(2,4-difluorophenyl)-1-(dimethylisopropoxysilyl)-3-(2-tetrahydropyranyloxy)-2-butanol (126918-18-1) → (2R,3R)-2-(2,4-Difluorophenyl)-3-(2-tetrahydropyranyloxy)-1,2-butanediol (126918-19-2)

Guidance literature:

With dihydrogen peroxide; sodium hydrogencarbonate; In tetrahydrofuran; methanol; at 70 ℃; for 1.5h;

DOI:10.1248/cpb.39.2241

Reference yield:

(2S,3R)-2-(2,4-Difluorophenyl)-1-(dimethylisopropoxysilyl)-3-(2-tetrahydropyranyloxy)-2-butanol → (2R,3R)-2-(2,4-Difluorophenyl)-3-(2-tetrahydropyranyloxy)-1,2-butanediol (126918-19-2)

Guidance literature:

With sodium chloride; dihydrogen peroxide; sodium hydrogencarbonate; In tetrahydrofuran; methanol; ethyl acetate;

upstream raw materials:

(2S^*,3R^*)-2-(2,4-Difluorophenyl)-1-(dimethylisopropoxysilyl)-3-(tetrahydropyran-2-yloxy)-2-butanol

1-(2,4-difluorophenyl)-2-(tetrahydropyranyloxy)propan-1-one

(2R,3S)-2-(2,4-Difluoro-phenyl)-1-(isopropoxy-dimethyl-silanyl)-3-(tetrahydro-pyran-2-yloxy)-butan-2-ol

3,4-dihydro-2H-pyran

Downstream raw materials:

(2S,3S)-2-(2,4-difluorophenyl)butane-1,2,3-triol

(2R,3R)-2-(2,4-difluorophenyl)butane-1,2,3-triol

(2R,3R)-2-(2,4-difluorophenyl)-2-hydroxybutane-1,3-diyl dimethanesulfonate

(2R,3R)-3-Azido-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol

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