(2R,3R)-2-(2,4-difluorophenyl)-2-hydroxybutane-1,3-diyl dimethanesulfonate

Base Information

Chemical Name:(2R,3R)-2-(2,4-difluorophenyl)-2-hydroxybutane-1,3-diyl dimethanesulfonate
CAS No.:126918-21-6
Molecular Formula:C₁₂H₁₆F₂O₇S₂
Molecular Weight:374.384
Hs Code.:

Synonyms:(2R,3R)-2-(2,4-difluorophenyl)-2-hydroxybutane-1,3-diyl dimethanesulfonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3R)-2-(2,4-difluorophenyl)-2-hydroxybutane-1,3-diyl dimethanesulfonate

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Technology Process of (2R,3R)-2-(2,4-difluorophenyl)-2-hydroxybutane-1,3-diyl dimethanesulfonate

There total 17 articles about (2R,3R)-2-(2,4-difluorophenyl)-2-hydroxybutane-1,3-diyl dimethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 126918-20-5
(2R,3R)-2-(2,4-difluorophenyl)butane-1,2,3-triol

: 124-63-0
methanesulfonyl chloride

: 126918-21-6
(2R,3R)-2-(2,4-difluorophenyl)-2-hydroxybutane-1,3-diyl dimethanesulfonate

Guidance literature:: With pyridine; at 0 ℃; for 0.5h;
DOI:10.1248/cpb.39.2241

Reference yield: 96.0%

: 126918-20-5,132563-67-8,138457-41-7
(2R^*,3R^*)-2-(2,4-Difluorophenyl)-1,2,3-butanetriol

: 124-63-0
methanesulfonyl chloride

: 126918-21-6,132563-68-9
(2R^*,3R^*)-2-(2,4-Difluorophenyl)-1,3-bis(methanesulfonyloxy)-2-butanol

Guidance literature:: With pyridine; at 0 ℃; for 0.5h;
DOI:10.1248/cpb.38.2476

Reference yield:

: 126918-14-7
(2S)-2',4'-Difluoro-2-hydroxypropiophenone

: 126918-21-6
(2R,3R)-2-(2,4-difluorophenyl)-2-hydroxybutane-1,3-diyl dimethanesulfonate

Guidance literature:: Multi-step reaction with 7 steps

1: 76 percent / pyridine / 0.5 h / 0 °C

2: aq. LiOH / dimethylformamide / 1 h / -15 °C

3: 87 percent / pyridinium p-toluenesulfonate / CH₂Cl₂ / Ambient temperature

4: 1) Mg / 1) ether, 3h, reflux, 2) THF, RT, 15 min

5: 35 percent / NaHCO₃, aq. H₂O₂ / tetrahydrofuran; methanol / 1.5 h / 70 °C

6: p-TsOH / methanol / 0.5 h / Ambient temperature

7: 96 percent / pyridine / 0.5 h / 0 °C

With pyridine; lithium hydroxide; dihydrogen peroxide; pyridinium p-toluenesulfonate; sodium hydrogencarbonate; toluene-4-sulfonic acid; magnesium; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.39.2241