Dimethyl 5-methyl-3-phenyl-1H,3H-pyrrolo[1,2-c][1,3]thiazole-6,7-dicarboxylate

Base Information

• Chemical Name: Dimethyl 5-methyl-3-phenyl-1H,3H-pyrrolo[1,2-c][1,3]thiazole-6,7-dicarboxylate
• CAS No.: 373599-95-2
• Molecular Formula: C₁₇H₁₇NO₄S
• Molecular Weight: 331.392
• Mol file: 373599-95-2.mol

Synonyms:Dimethyl 5-methyl-3-phenyl-1H,3H-pyrrolo[1,2-c][1,3]thiazole-6,7-dicarboxylate

Chemical Property of Dimethyl 5-methyl-3-phenyl-1H,3H-pyrrolo[1,2-c][1,3]thiazole-6,7-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Dimethyl 5-methyl-3-phenyl-1H,3H-pyrrolo[1,2-c][1,3]thiazole-6,7-dicarboxylate

There total 2 articles about Dimethyl 5-methyl-3-phenyl-1H,3H-pyrrolo[1,2-c][1,3]thiazole-6,7-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

(4R)-2-phenyl-1,3-thiazolidine-4-carboxylic acid (196930-46-8) + acetic anhydride (108-24-7) + dimethyl acetylenedicarboxylate (762-42-5) → Dimethyl 5-methyl-3-phenyl-1H,3H-pyrrolo[1,2-c][1,3]thiazole-6,7-dicarboxylate (373599-95-2)

Guidance literature:

for 3h; Heating;

DOI:10.1039/b103250j

Reference yield:

benzaldehyde (100-52-7) → Dimethyl 5-methyl-3-phenyl-1H,3H-pyrrolo[1,2-c][1,3]thiazole-6,7-dicarboxylate (373599-95-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 67 percent / H₂O / 1 h / 0 °C

2: 68 percent / 3 h / Heating

In water;

DOI:10.1039/b103250j

Reference yield: 94.0%

Dimethyl 5-methyl-3-phenyl-1H,3H-pyrrolo[1,2-c][1,3]thiazole-6,7-dicarboxylate (373599-95-2) → Dimethyl 2,2-dioxo-5-methyl-3-phenyl-1H,3H-pyrrolo[1,2-c][1,3]thiazole-6,7-dicarboxylate

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 - 20 ℃; for 4h;

DOI:10.1039/b103250j

upstream raw materials:

(4R)-2-phenyl-1,3-thiazolidine-4-carboxylic acid

acetic anhydride

dimethyl acetylenedicarboxylate

benzaldehyde