N-(4-(((4-(3-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)methyl)pyridin-2-yl)-2-(methylsulfonyl)acetamide

Base Information

Chemical Name:N-(4-(((4-(3-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)methyl)pyridin-2-yl)-2-(methylsulfonyl)acetamide
CAS No.:1229649-18-6
Molecular Formula:C₃₄H₃₆N₆O₅S
Molecular Weight:640.763
Hs Code.:

Synonyms:N-(4-(((4-(3-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)methyl)pyridin-2-yl)-2-(methylsulfonyl)acetamide

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Chemical Property of N-(4-(((4-(3-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)methyl)pyridin-2-yl)-2-(methylsulfonyl)acetamide

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Technology Process of N-(4-(((4-(3-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)methyl)pyridin-2-yl)-2-(methylsulfonyl)acetamide

There total 8 articles about N-(4-(((4-(3-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)methyl)pyridin-2-yl)-2-(methylsulfonyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

: 2516-97-4
2-(methylsulfonyl)acetic acid

: 1220627-08-6
1-(4-((2-aminopyridin-4-yl)methoxy)naphthalen-1-yl)-3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)urea

: 1229649-18-6
N-(4-(((4-(3-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)methyl)pyridin-2-yl)-2-(methylsulfonyl)acetamide

Guidance literature:: 2-(methylsulfonyl)acetic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 1h;

1-(4-((2-aminopyridin-4-yl)methoxy)naphthalen-1-yl)-3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)urea; With N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; for 18h;

Reference yield: 18.0%

: 56841-99-7
methylsulphonylacetyl chloride

: 1220627-08-6
1-(4-((2-aminopyridin-4-yl)methoxy)naphthalen-1-yl)-3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)urea

: 1229649-18-6
N-(4-(((4-(3-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)methyl)pyridin-2-yl)-2-(methylsulfonyl)acetamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 18h;
DOI:10.1021/acs.jmedchem.5b01029

Reference yield:

: 79-37-8
oxalyl dichloride

: 2516-97-4
2-(methylsulfonyl)acetic acid

: 1229649-18-6
N-(4-(((4-(3-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)methyl)pyridin-2-yl)-2-(methylsulfonyl)acetamide

Guidance literature:: With DIPEA; ammonia; In methanol; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; N,N-dimethyl-formamide;