1-(2-fluorophenyl)-4-(2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl)piperazine

Base Information

Chemical Name:1-(2-fluorophenyl)-4-(2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl)piperazine
CAS No.:1175005-77-2
Molecular Formula:C₁₆H₂₀FN₅O₂
Molecular Weight:333.366
Hs Code.:

Synonyms:1-(2-fluorophenyl)-4-(2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl)piperazine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(2-fluorophenyl)-4-(2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl)piperazine

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Technology Process of 1-(2-fluorophenyl)-4-(2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl)piperazine

There total 3 articles about 1-(2-fluorophenyl)-4-(2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 30575-42-9
toluene-4-sulfonic acid 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl ester

: 1011-15-0
1-(o-fluorophenyl)piperazine

: 1175005-77-2
1-(2-fluorophenyl)-4-(2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl)piperazine

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃;
DOI:10.1016/j.bmc.2014.03.004

Reference yield: 46.0%

: 6058-57-7
1-(2-bromoethyl)-2-methyl-5-nitroimidazole

: 1011-15-0
1-(o-fluorophenyl)piperazine

: 1175005-77-2
1-(2-fluorophenyl)-4-(2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl)piperazine

Guidance literature:: With potassium carbonate; sodium iodide; In toluene; for 24h; Reflux;

Reference yield:

: 443-48-1
metronidazole

: 1175005-77-2
1-(2-fluorophenyl)-4-(2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl)piperazine

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 5 h / 0 °C

2: potassium carbonate / N,N-dimethyl-formamide / 80 °C

With potassium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2014.03.004