1-(cyclopropylmethyl)-5-hydroxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one

Base Information

Chemical Name:1-(cyclopropylmethyl)-5-hydroxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one
CAS No.:1357358-06-5
Molecular Formula:C₁₇H₁₆N₄O₂
Molecular Weight:308.34
Hs Code.:

Synonyms:1-(cyclopropylmethyl)-5-hydroxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one

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Chemical Property of 1-(cyclopropylmethyl)-5-hydroxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one

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Technology Process of 1-(cyclopropylmethyl)-5-hydroxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one

There total 6 articles about 1-(cyclopropylmethyl)-5-hydroxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1357358-05-4
1-(cyclopropylmethyl)-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one

: 1357358-06-5
1-(cyclopropylmethyl)-5-hydroxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one

Guidance literature:: With chloro-trimethyl-silane; sodium iodide; In acetonitrile; for 4h; Reflux;
DOI:10.1016/j.bmc.2016.05.049

Reference yield:

: 1357192-31-4
1-benzyl-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one

: 1357358-06-5
1-(cyclopropylmethyl)-5-hydroxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen; 20% palladium hydroxide-activated charcoal / tetrahydrofuran; methanol / 48 h / 20 °C

2.1: sodium hydride / mineral oil; N,N-dimethyl acetamide / 1.5 h / Cooling with ice; Inert atmosphere

2.2: 16 h / 20 °C

3.1: sodium iodide; chloro-trimethyl-silane / acetonitrile / 4.5 h / 20 °C / Reflux

With chloro-trimethyl-silane; 20% palladium hydroxide-activated charcoal; hydrogen; sodium hydride; sodium iodide; In tetrahydrofuran; methanol; N,N-dimethyl acetamide; acetonitrile; mineral oil;

Reference yield:

: 1357192-32-5
5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4-ol

: 1357358-06-5
1-(cyclopropylmethyl)-5-hydroxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / mineral oil; N,N-dimethyl acetamide / 1.5 h / Cooling with ice; Inert atmosphere

1.2: 16 h / 20 °C

2.1: sodium iodide; chloro-trimethyl-silane / acetonitrile / 4.5 h / 20 °C / Reflux

With chloro-trimethyl-silane; sodium hydride; sodium iodide; In N,N-dimethyl acetamide; acetonitrile; mineral oil;