1-(cyclopropylmethyl)-5-[2-(2,3-dihydro-1H-imidazo[1,2-a]benzimidazol-1-yl)ethoxy]-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one

Base Information

Chemical Name:1-(cyclopropylmethyl)-5-[2-(2,3-dihydro-1H-imidazo[1,2-a]benzimidazol-1-yl)ethoxy]-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one
CAS No.:1357357-77-7
Molecular Formula:C₂₈H₂₇N₇O₂
Molecular Weight:493.568
Hs Code.:

Synonyms:1-(cyclopropylmethyl)-5-[2-(2,3-dihydro-1H-imidazo[1,2-a]benzimidazol-1-yl)ethoxy]-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one

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Chemical Property of 1-(cyclopropylmethyl)-5-[2-(2,3-dihydro-1H-imidazo[1,2-a]benzimidazol-1-yl)ethoxy]-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one

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Technology Process of 1-(cyclopropylmethyl)-5-[2-(2,3-dihydro-1H-imidazo[1,2-a]benzimidazol-1-yl)ethoxy]-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one

There total 7 articles about 1-(cyclopropylmethyl)-5-[2-(2,3-dihydro-1H-imidazo[1,2-a]benzimidazol-1-yl)ethoxy]-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1357358-06-5
1-(cyclopropylmethyl)-5-hydroxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one

: 118517-62-7
1-(2-chloroethyl)-2,3-dihydro-1H-imidazo<1,2-a>benzimidazole

: 1357357-77-7
1-(cyclopropylmethyl)-5-[2-(2,3-dihydro-1H-imidazo[1,2-a]benzimidazol-1-yl)ethoxy]-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one

Guidance literature:: With caesium carbonate; sodium iodide; In N,N-dimethyl acetamide; at 80 ℃; for 13h;
DOI:10.1016/j.bmc.2016.05.049

Reference yield:

: 1357192-32-5
5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4-ol

: 1357357-77-7
1-(cyclopropylmethyl)-5-[2-(2,3-dihydro-1H-imidazo[1,2-a]benzimidazol-1-yl)ethoxy]-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / mineral oil; N,N-dimethyl acetamide / 1.5 h / Cooling with ice; Inert atmosphere

1.2: 16 h / 20 °C

2.1: sodium iodide; chloro-trimethyl-silane / acetonitrile / 4.5 h / 20 °C / Reflux

3.1: sodium iodide; caesium carbonate / N,N-dimethyl acetamide / 13 h / 80 °C

With chloro-trimethyl-silane; sodium hydride; caesium carbonate; sodium iodide; In N,N-dimethyl acetamide; acetonitrile; mineral oil;

Reference yield:

: 1357358-05-4
1-(cyclopropylmethyl)-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one

: 1357357-77-7
1-(cyclopropylmethyl)-5-[2-(2,3-dihydro-1H-imidazo[1,2-a]benzimidazol-1-yl)ethoxy]-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: sodium iodide; chloro-trimethyl-silane / acetonitrile / 4.5 h / 20 °C / Reflux

2: sodium iodide; caesium carbonate / N,N-dimethyl acetamide / 13 h / 80 °C

With chloro-trimethyl-silane; caesium carbonate; sodium iodide; In N,N-dimethyl acetamide; acetonitrile;