1-(3,5-di-O-benzoyl-2-deoxypentofuranosyl)-5-fluoropyrimidine-2,4(1H,3H)-dione

Base Information

Chemical Name:1-(3,5-di-O-benzoyl-2-deoxypentofuranosyl)-5-fluoropyrimidine-2,4(1H,3H)-dione
CAS No.:2691-71-6
Molecular Formula:C23H19 F N2 O7
Molecular Weight:454.411
Hs Code.:

Synonyms:3',5'-Di-O-benzoyl-5-fluoro-2'-deoxyuridine;5-Fluoro-2'-deoxyuridine 3',5'-dibenzoate; NSC 521791

Suppliers and Price of 1-(3,5-di-O-benzoyl-2-deoxypentofuranosyl)-5-fluoropyrimidine-2,4(1H,3H)-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 10 raw suppliers

Chemical Property of 1-(3,5-di-O-benzoyl-2-deoxypentofuranosyl)-5-fluoropyrimidine-2,4(1H,3H)-dione

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
Density:1.45g/cm³

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-(3,5-di-O-benzoyl-2-deoxypentofuranosyl)-5-fluoropyrimidine-2,4(1H,3H)-dione

There total 7 articles about 1-(3,5-di-O-benzoyl-2-deoxypentofuranosyl)-5-fluoropyrimidine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 769-78-8,24991-32-0
vinyl benzoate

: 50-91-9
5-Fluoro-2'-deoxyuridine

: 1006381-74-3
5'-O-benzoyl-FUdR

: 1995-83-1
(2R,3S,5R)-5-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-(hydroxymethyl)tetrahydrofuran-3-yl benzoate

: 2691-71-6
3',5'-di-O-benzoyl-5-fluoro-2'-deoxyuridine

Guidance literature:: With PSL-C; 1-n-butyl-2,3-dimethylimidazolium hexafluorophosphate; In tetrahydrofuran; at 50 ℃; for 66h; Time; Temperature; regioselective reaction; Reactivity;
DOI:10.1016/j.tet.2008.11.045

Reference yield: 53.0%

: 182004-60-0
3',5'-di-O-benzoyl-2'-O-[3-(trifluoromethyl)benzoyl]-5-fluorouridine

: 2691-71-6
3',5'-di-O-benzoyl-5-fluoro-2'-deoxyuridine

Guidance literature:: With magnesium(II) perchlorate; N-methylcarbazole; In water; isopropyl alcohol; at 25 ℃; Irradiation;
DOI:10.1021/jo960936j

Reference yield:

: 22224-41-5
1,3,5-tri-O-benzoyl-α-D-ribofuranoside

: 2691-71-6
3',5'-di-O-benzoyl-5-fluoro-2'-deoxyuridine

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / 2,6-lutidine / CH₂Cl₂ / 2.5 h / 20 °C

2: 91 percent / SnCl₄ / acetonitrile / 20 °C

3: 53 percent / 9-methylcarbazole; Mg(ClO₄)2*6H₂O / propan-2-ol; H₂O / 25 °C / Photolysis

With 2,6-dimethylpyridine; magnesium(II) perchlorate; N-methylcarbazole; tin(IV) chloride; In dichloromethane; water; isopropyl alcohol; acetonitrile; 1: Acylation / 2: Substitution / 3: Elimination;
DOI:10.1021/jo0003652