2691-71-6

Usage

Uses

Used in Pharmaceutical Industry:
1-(3,5-di-O-benzoyl-2-deoxypentofuranosyl)-5-fluoropyrimidine-2,4(1H,3H)-dione is used as an antiviral and anticancer agent for its ability to inhibit the synthesis of DNA and RNA. This property helps in suppressing the growth of cancer cells and treating certain viral infections.
Used in Drug Development:
In the field of drug development, 1-(3,5-di-O-benzoyl-2-deoxypentofuranosyl)-5-fluoropyrimidine-2,4(1H,3H)-dione serves as a key component in the creation of novel therapeutic agents. Its stability and bioavailability, enhanced by the 1-(3,5-di-O-benzoyl-2-deoxypentofuranosyl) substituent, make it a promising candidate for the advancement of new medications targeting cancer and viral diseases.

Upstream product

• 145828-13-3 α-D-1,3,5-tri-O-benzoyl-2-O-[3-(trifluoromethyl)benzoyl]ribofuranose 
• 22224-41-5 1,3,5-tri-O-benzoyl-α-D-ribofuranoside 
• 769-78-8 vinyl benzoate 
• 50-91-9 5-Fluoro-2'-deoxyuridine 
• 98-88-4 benzoyl chloride 
• 41545-90-8 1-(O³,O⁵-dibenzoyl-α-L-erythro-2-deoxy-pentofuranosyl)-1H-pyrimidine-2,4-dione 
• 182004-60-0 3',5'-di-O-benzoyl-2'-O-[3-(trifluoromethyl)benzoyl]-5-fluorouridine 

Downstream Products

• 50-91-9 5-Fluoro-2'-deoxyuridine 

Relevant academic research and scientific papers

High purity 5 - fluoro - deoxy uracil nucleoside preparation method

The invention discloses a preparation method of high-purity 5-fluro-deoxyuridine. The preparation method comprises the following steps: (A) mixing a 5-fluro-deoxyuridine derivative as shown in a structural formula B and a reagent capable of removing hydroxyl protecting groups, and reacting at the temperature of 5-40 DEG C, thereby obtaining a reaction system A; (B) dissolving the reaction system A in an organic solvent, and crystallizing at the temperature of 0-15 DEG C, thereby obtaining the 5-fluro-deoxyuridine as shown in a structural formula A. The reagent for removing the hydroxyl protecting groups is selected from ammonia water and methanol amine, an aqueous solution of sodium hydroxide and potassium hydroxide, glacial acetic acid, trifluoroacetic acid or tetrabutylammonium fluoride.

Regioselective acylation of nucleosides and their analogs catalyzed by Pseudomonas cepacia lipase: enzyme substrate recognition

The substrate recognition of Pseudomonas cepacia lipase in the acylation of nucleosides was investigated by means of rational substrate engineering for the first time. P. cepacia lipase displayed excellent 3′-regioselectivities (96 to >99%) in the lauroyl

Stereocontrolled Syntheses of Deoxyribonucleosides via Photoinduced Electron-Transfer Deoxygenation of Benzoyl-Protected Ribo- and Arabinonucleosides

The stereocontrolled, de novo syntheses of β-2′-deoxy-, α-2′-deoxy-, β-3′-deoxy-, and β-2′,3′-dideoxyribonucleosides are described. Strategically protected ribose, arabinose, and xylose glycosylation precursors were synthesized bearing C2-esters capable of directing Vorbrueggen glycosylation. The key step is the regioselective deoxygenation of the desired hydroxyl group as either the benzoyl- or 3-(trifluoromethyl)benzoyl derivative. This deoxygenation is accomplished via a photoinduced electron-transfer (PET) mechanism using carbazole derivatives as the photosensitizer. The syntheses of the desired deoxynucleoside generally proceed in three steps from a common, readily available precursor.