ethyl 3-(1-((4-(1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamido)phenyl)sulfonyl)piperidin-2-yl)propanoate

Base Information

Chemical Name:ethyl 3-(1-((4-(1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamido)phenyl)sulfonyl)piperidin-2-yl)propanoate
CAS No.:1374006-90-2
Molecular Formula:C₂₂H₂₇F₃N₄O₅S
Molecular Weight:516.541
Hs Code.:

Synonyms:ethyl 3-(1-((4-(1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamido)phenyl)sulfonyl)piperidin-2-yl)propanoate

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Chemical Property of ethyl 3-(1-((4-(1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamido)phenyl)sulfonyl)piperidin-2-yl)propanoate

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Technology Process of ethyl 3-(1-((4-(1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamido)phenyl)sulfonyl)piperidin-2-yl)propanoate

There total 9 articles about ethyl 3-(1-((4-(1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamido)phenyl)sulfonyl)piperidin-2-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: ethyl 3-(1-((4-(1-methyl-3-(trifluoromethyl)pyrazole-5-carboxamido)phenyl)sulfonyl)piperidin-2-yl)acrylate

: 1374006-90-2
ethyl 3-(1-((4-(1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamido)phenyl)sulfonyl)piperidin-2-yl)propanoate

Guidance literature:: With palladium on activated charcoal; hydrogen; In methanol;

Reference yield:

: 1374006-88-8
(E)-ethyl 3-(1-((4-(1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamido)phenyl)sulfonyl)piperidin-2-yl)acrylate

: 1374006-90-2
ethyl 3-(1-((4-(1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamido)phenyl)sulfonyl)piperidin-2-yl)propanoate

Guidance literature:: With palladium on activated charcoal; hydrogen; In methanol; for 1h;
DOI:10.1021/jm201699w

Reference yield:

: 98-74-8
4-Nitrobenzenesulfonyl chloride

: 1374006-90-2
ethyl 3-(1-((4-(1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamido)phenyl)sulfonyl)piperidin-2-yl)propanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium carbonate / acetone / 10 h / 20 °C

2.1: pyridinium chlorochromate / dichloromethane

3.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 0 °C

3.2: 20 °C

4.1: tin(II) chloride dihdyrate / ethyl acetate / 6 h / 20 °C

5.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 0 °C

5.2: 2 h

6.1: palladium on activated charcoal; hydrogen / methanol / 1 h

With oxalyl dichloride; tin(II) chloride dihdyrate; palladium on activated charcoal; potassium tert-butylate; hydrogen; sodium carbonate; N,N-dimethyl-formamide; pyridinium chlorochromate; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; acetone;
DOI:10.1021/jm201699w