(E)-ethyl 3-(1-((4-(1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamido)phenyl)sulfonyl)piperidin-2-yl)acrylate

Base Information

Chemical Name:(E)-ethyl 3-(1-((4-(1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamido)phenyl)sulfonyl)piperidin-2-yl)acrylate
CAS No.:1374006-88-8
Molecular Formula:C₂₂H₂₅F₃N₄O₅S
Molecular Weight:514.526
Hs Code.:

Synonyms:(E)-ethyl 3-(1-((4-(1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamido)phenyl)sulfonyl)piperidin-2-yl)acrylate

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Chemical Property of (E)-ethyl 3-(1-((4-(1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamido)phenyl)sulfonyl)piperidin-2-yl)acrylate

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Technology Process of (E)-ethyl 3-(1-((4-(1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamido)phenyl)sulfonyl)piperidin-2-yl)acrylate

There total 6 articles about (E)-ethyl 3-(1-((4-(1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamido)phenyl)sulfonyl)piperidin-2-yl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₆H₂₂N₂O₄S

: 128694-63-3
1-methyl-3-(trifluoromethyl)pyrazole-5-carboxylic acid

: 1374006-88-8
(E)-ethyl 3-(1-((4-(1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamido)phenyl)sulfonyl)piperidin-2-yl)acrylate

Guidance literature:: 1-methyl-3-(trifluoromethyl)pyrazole-5-carboxylic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 0 ℃; for 1h;

C₁₆H₂₂N₂O₄S; With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 2h;
DOI:10.1021/jm201699w

Reference yield:

: 349098-93-7
C₁₂H₁₆N₂O₅S

: 1374006-88-8
(E)-ethyl 3-(1-((4-(1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamido)phenyl)sulfonyl)piperidin-2-yl)acrylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridinium chlorochromate / dichloromethane

2.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 0 °C

2.2: 20 °C

3.1: tin(II) chloride dihdyrate / ethyl acetate / 6 h / 20 °C

4.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 0 °C

4.2: 2 h

With oxalyl dichloride; tin(II) chloride dihdyrate; potassium tert-butylate; N,N-dimethyl-formamide; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1021/jm201699w

Reference yield:

: 1374007-01-8
C₁₆H₂₀N₂O₆S

: 1374006-88-8
(E)-ethyl 3-(1-((4-(1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamido)phenyl)sulfonyl)piperidin-2-yl)acrylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: tin(II) chloride dihdyrate / ethyl acetate / 6 h / 20 °C

2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 0 °C

2.2: 2 h

With oxalyl dichloride; tin(II) chloride dihdyrate; N,N-dimethyl-formamide; In dichloromethane; ethyl acetate;
DOI:10.1021/jm201699w