N-(4-((2-(3-hydroxypropyl)piperidin-1-yl)sulfonyl)phenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

Base Information

Chemical Name:N-(4-((2-(3-hydroxypropyl)piperidin-1-yl)sulfonyl)phenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide
CAS No.:1374006-91-3
Molecular Formula:C₂₀H₂₅F₃N₄O₄S
Molecular Weight:474.504
Hs Code.:

Synonyms:N-(4-((2-(3-hydroxypropyl)piperidin-1-yl)sulfonyl)phenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

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Chemical Property of N-(4-((2-(3-hydroxypropyl)piperidin-1-yl)sulfonyl)phenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

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Technology Process of N-(4-((2-(3-hydroxypropyl)piperidin-1-yl)sulfonyl)phenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

There total 10 articles about N-(4-((2-(3-hydroxypropyl)piperidin-1-yl)sulfonyl)phenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1374006-90-2
ethyl 3-(1-((4-(1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamido)phenyl)sulfonyl)piperidin-2-yl)propanoate

: 1374006-91-3
N-(4-((2-(3-hydroxypropyl)piperidin-1-yl)sulfonyl)phenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

Guidance literature:: With diisobutylaluminium hydride; In tetrahydrofuran; hexane; at 0 ℃; for 1h;
DOI:10.1021/jm201699w

Reference yield:

: 1374006-88-8
(E)-ethyl 3-(1-((4-(1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamido)phenyl)sulfonyl)piperidin-2-yl)acrylate

: 1374006-91-3
N-(4-((2-(3-hydroxypropyl)piperidin-1-yl)sulfonyl)phenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: palladium on activated charcoal; hydrogen / methanol / 1 h

2: diisobutylaluminium hydride / tetrahydrofuran; hexane / 1 h / 0 °C

With palladium on activated charcoal; hydrogen; diisobutylaluminium hydride; In tetrahydrofuran; methanol; hexane;
DOI:10.1021/jm201699w

Reference yield:

: 98-74-8
4-Nitrobenzenesulfonyl chloride

: 1374006-91-3
N-(4-((2-(3-hydroxypropyl)piperidin-1-yl)sulfonyl)phenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium carbonate / acetone / 10 h / 20 °C

2.1: pyridinium chlorochromate / dichloromethane

3.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 0 °C

3.2: 20 °C

4.1: tin(II) chloride dihdyrate / ethyl acetate / 6 h / 20 °C

5.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 0 °C

5.2: 2 h

6.1: palladium on activated charcoal; hydrogen / methanol / 1 h

7.1: diisobutylaluminium hydride / tetrahydrofuran; hexane / 1 h / 0 °C

With oxalyl dichloride; tin(II) chloride dihdyrate; palladium on activated charcoal; potassium tert-butylate; hydrogen; diisobutylaluminium hydride; sodium carbonate; N,N-dimethyl-formamide; pyridinium chlorochromate; In tetrahydrofuran; methanol; hexane; dichloromethane; ethyl acetate; acetone;
DOI:10.1021/jm201699w