Technology Process of 3,5-dichloro-4-[7-fluoro-4-(6-methylpyrimidin-4-ylamino)thiazolo[5,4-c]pyridin-2-yl]-benzonitrile formate salt
There total 8 articles about 3,5-dichloro-4-[7-fluoro-4-(6-methylpyrimidin-4-ylamino)thiazolo[5,4-c]pyridin-2-yl]-benzonitrile formate salt which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
6-methylpyrimidin-4-ylamine; 4-(4-bromo-7-fluorothiazolo[5,4-c]pyridin-2-yl)-3,5-dichlorobenzonitrile;
With
caesium carbonate;
tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene;
In
1,4-dioxane;
at 80 ℃;
for 18h;
Inert atmosphere;
formic acid;
In
methanol; water;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sodium hydride / N,N-dimethyl-formamide / 0 °C / Inert atmosphere
1.2: 10 °C / Inert atmosphere
2.1: thionyl chloride / 61 h / 80 - 85 °C / Inert atmosphere
3.1: thiourea; pyridine / isopropyl alcohol / 4 h / 90 °C / Inert atmosphere
3.2: 60 - 90 °C
4.1: dihydrogen peroxide / methyltrioxorhenium(VII) / dichloromethane; water / 18 h / 20 °C / Inert atmosphere
5.1: trichlorophosphate / 1 h / 110 °C / Inert atmosphere
6.1: trimethylsilyl bromide / propiononitrile / 20 - 85 °C / Inert atmosphere
7.1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane / 18 h / 80 °C / Inert atmosphere
With
pyridine; thionyl chloride; trimethylsilyl bromide; dihydrogen peroxide; sodium hydride; caesium carbonate; thiourea; trichlorophosphate;
tris-(dibenzylideneacetone)dipalladium(0); methyltrioxorhenium(VII); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene;
In
1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; propiononitrile;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sodium hydride / N,N-dimethyl-formamide / 0 °C / Inert atmosphere
1.2: 10 °C / Inert atmosphere
2.1: thionyl chloride / 61 h / 80 - 85 °C / Inert atmosphere
3.1: thiourea; pyridine / isopropyl alcohol / 4 h / 90 °C / Inert atmosphere
3.2: 60 - 90 °C
4.1: dihydrogen peroxide / methyltrioxorhenium(VII) / dichloromethane; water / 18 h / 20 °C / Inert atmosphere
5.1: trichlorophosphate / 1 h / 110 °C / Inert atmosphere
6.1: trimethylsilyl bromide / propiononitrile / 20 - 85 °C / Inert atmosphere
7.1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane / 18 h / 80 °C / Inert atmosphere
With
pyridine; thionyl chloride; trimethylsilyl bromide; dihydrogen peroxide; sodium hydride; caesium carbonate; thiourea; trichlorophosphate;
tris-(dibenzylideneacetone)dipalladium(0); methyltrioxorhenium(VII); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene;
In
1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; propiononitrile;
