2-[(tert-butyldimethylsilyloxy)methyl]-N-[(2S)-2-(1-methoxy-3-methylbutyl)]-benzamide

Base Information

• Chemical Name: 2-[(tert-butyldimethylsilyloxy)methyl]-N-[(2S)-2-(1-methoxy-3-methylbutyl)]-benzamide
• CAS No.: 777944-40-8
• Molecular Formula: C₂₀H₃₅NO₃Si
• Molecular Weight: 365.588

Synonyms:2-[(tert-butyldimethylsilyloxy)methyl]-N-[(2S)-2-(1-methoxy-3-methylbutyl)]-benzamide

Chemical Property of 2-[(tert-butyldimethylsilyloxy)methyl]-N-[(2S)-2-(1-methoxy-3-methylbutyl)]-benzamide

Chemical Property:

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Technology Process of 2-[(tert-butyldimethylsilyloxy)methyl]-N-[(2S)-2-(1-methoxy-3-methylbutyl)]-benzamide

There total 3 articles about 2-[(tert-butyldimethylsilyloxy)methyl]-N-[(2S)-2-(1-methoxy-3-methylbutyl)]-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

tert-butyldimethylsilyl chloride (18162-48-6) + 2-(hydroxymethyl)-N-[(2S)-(1-methoxy-3-methylbutyl)]-benzamide (777944-38-4) → 2-[(tert-butyldimethylsilyloxy)methyl]-N-[(2S)-2-(1-methoxy-3-methylbutyl)]-benzamide (777944-40-8)

Guidance literature:

With 1H-imidazole; In tetrahydrofuran; at 20 ℃;

DOI:10.1021/ol048624n

Reference yield:

2-benzofuran-1(3H)-one (87-41-2) → 2-[(tert-butyldimethylsilyloxy)methyl]-N-[(2S)-2-(1-methoxy-3-methylbutyl)]-benzamide (777944-40-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 68 percent / Me₃Al / CH₂Cl₂; hexane / 40 °C

2: 91 percent / imidazole / tetrahydrofuran / 20 °C

With 1H-imidazole; trimethylaluminum; In tetrahydrofuran; hexane; dichloromethane;

DOI:10.1021/ol048624n

Reference yield:

(S)-2-amino-1-methoxy-3-methylbutane (64715-88-4) → 2-[(tert-butyldimethylsilyloxy)methyl]-N-[(2S)-2-(1-methoxy-3-methylbutyl)]-benzamide (777944-40-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 68 percent / Me₃Al / CH₂Cl₂; hexane / 40 °C

2: 91 percent / imidazole / tetrahydrofuran / 20 °C

With 1H-imidazole; trimethylaluminum; In tetrahydrofuran; hexane; dichloromethane;

DOI:10.1021/ol048624n

upstream raw materials:

tert-butyldimethylsilyl chloride

2-(hydroxymethyl)-N-[(2S)-(1-methoxy-3-methylbutyl)]-benzamide

2-benzofuran-1(3H)-one

(S)-2-amino-1-methoxy-3-methylbutane

Downstream raw materials:

[1-[2-(tert-Butyl-dimethyl-silanyloxymethyl)-phenyl]-1-((R)-2-methyl-2H-pyridin-1-yl)-meth-(E)-ylidene]-((S)-1-methoxymethyl-2-methyl-propyl)-amine

N-{(1E)-[2-({[tert-butyl(dimethyl)silyl]oxy}methyl)phenyl][(2R)-5-iodo-2-methyl-3,4-dihydropyridin-1(2H)-yl]methylidene}-N-[(1S)-1-(methoxymethyl)-2-methylpropyl]amine

N-{(1E)-[2-({[tert-butyl(dimethyl)silyl]oxy}methyl)phenyl][(2R)-2-methyl-3,4-dihydropyridin-1(2H)-yl]methylidene}-N-[(1S)-1-(methoxymethyl)-2-methylpropyl]amine

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