[1-[2-(tert-Butyl-dimethyl-silanyloxymethyl)-phenyl]-1-((R)-2-methyl-2H-pyridin-1-yl)-meth-(E)-ylidene]-((S)-1-methoxymethyl-2-methyl-propyl)-amine

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Chemical Name:[1-[2-(tert-Butyl-dimethyl-silanyloxymethyl)-phenyl]-1-((R)-2-methyl-2H-pyridin-1-yl)-meth-(E)-ylidene]-((S)-1-methoxymethyl-2-methyl-propyl)-amine
CAS No.:911694-31-0
Molecular Formula:C₂₆H₄₂N₂O₂Si
Molecular Weight:442.717
Hs Code.:

Synonyms:[1-[2-(tert-Butyl-dimethyl-silanyloxymethyl)-phenyl]-1-((R)-2-methyl-2H-pyridin-1-yl)-meth-(E)-ylidene]-((S)-1-methoxymethyl-2-methyl-propyl)-amine

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Chemical Property of [1-[2-(tert-Butyl-dimethyl-silanyloxymethyl)-phenyl]-1-((R)-2-methyl-2H-pyridin-1-yl)-meth-(E)-ylidene]-((S)-1-methoxymethyl-2-methyl-propyl)-amine

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Technology Process of [1-[2-(tert-Butyl-dimethyl-silanyloxymethyl)-phenyl]-1-((R)-2-methyl-2H-pyridin-1-yl)-meth-(E)-ylidene]-((S)-1-methoxymethyl-2-methyl-propyl)-amine

There total 1 articles about [1-[2-(tert-Butyl-dimethyl-silanyloxymethyl)-phenyl]-1-((R)-2-methyl-2H-pyridin-1-yl)-meth-(E)-ylidene]-((S)-1-methoxymethyl-2-methyl-propyl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 110-86-1
pyridine

: 75-16-1
methylmagnesium bromide

: 777944-40-8
2-[(tert-butyldimethylsilyloxy)methyl]-N-[(2S)-2-(1-methoxy-3-methylbutyl)]-benzamide

: 911694-31-0
[1-[2-(tert-Butyl-dimethyl-silanyloxymethyl)-phenyl]-1-((R)-2-methyl-2H-pyridin-1-yl)-meth-(E)-ylidene]-((S)-1-methoxymethyl-2-methyl-propyl)-amine

Guidance literature:: pyridine; 2-[(tert-butyldimethylsilyloxy)methyl]-N-[(2S)-2-(1-methoxy-3-methylbutyl)]-benzamide; With trifluoromethylsulfonic anhydride; In dichloromethane; at -40 - 20 ℃;

methylmagnesium bromide; In diethyl ether; dichloromethane; at -78 ℃;
DOI:10.1021/ol061415d

Reference yield: 79.0%

: 911694-31-0
[1-[2-(tert-Butyl-dimethyl-silanyloxymethyl)-phenyl]-1-((R)-2-methyl-2H-pyridin-1-yl)-meth-(E)-ylidene]-((S)-1-methoxymethyl-2-methyl-propyl)-amine

: 911694-11-6
N-{(1E)-[2-({[tert-butyl(dimethyl)silyl]oxy}methyl)phenyl][(2R)-2-methyl-3,4-dihydropyridin-1(2H)-yl]methylidene}-N-[(1S)-1-(methoxymethyl)-2-methylpropyl]amine

Guidance literature:: With hydrogen; palladium on activated charcoal; In acetonitrile; at 20 ℃; for 2h; under 750.06 Torr;
DOI:10.1021/ol061415d

Reference yield:

: 911694-31-0
[1-[2-(tert-Butyl-dimethyl-silanyloxymethyl)-phenyl]-1-((R)-2-methyl-2H-pyridin-1-yl)-meth-(E)-ylidene]-((S)-1-methoxymethyl-2-methyl-propyl)-amine

: 911694-15-0
N-{(1E)-[2-({[tert-butyl(dimethyl)silyl]oxy}methyl)phenyl][(2R)-5-iodo-2-methyl-3,4-dihydropyridin-1(2H)-yl]methylidene}-N-[(1S)-1-(methoxymethyl)-2-methylpropyl]amine

Guidance literature:: Multi-step reaction with 2 steps

1: 79 percent / H₂ / Pd/C / acetonitrile / 2 h / 20 °C / 750.06 Torr

2: 73 percent / I₂; Cs₂CO₃ / dioxane / 12 h / 65 °C

With hydrogen; iodine; caesium carbonate; palladium on activated charcoal; In 1,4-dioxane; acetonitrile;
DOI:10.1021/ol061415d