2-(3-benzoyl-4-hydroxy-1,1-dioxido-2H-benzo[e][1,2]thiazin-2-yl)-N-ethylacetamide

Base Information

Chemical Name:2-(3-benzoyl-4-hydroxy-1,1-dioxido-2H-benzo[e][1,2]thiazin-2-yl)-N-ethylacetamide
CAS No.:1310459-48-3
Molecular Formula:C₁₉H₁₈N₂O₅S
Molecular Weight:386.428
Hs Code.:

Synonyms:2-(3-benzoyl-4-hydroxy-1,1-dioxido-2H-benzo[e][1,2]thiazin-2-yl)-N-ethylacetamide

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Chemical Property of 2-(3-benzoyl-4-hydroxy-1,1-dioxido-2H-benzo[e][1,2]thiazin-2-yl)-N-ethylacetamide

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Technology Process of 2-(3-benzoyl-4-hydroxy-1,1-dioxido-2H-benzo[e][1,2]thiazin-2-yl)-N-ethylacetamide

There total 6 articles about 2-(3-benzoyl-4-hydroxy-1,1-dioxido-2H-benzo[e][1,2]thiazin-2-yl)-N-ethylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 61018-80-2
(4-hydroxy-1,1-dioxo-1,2-dihydro-1λ⁶-benzo[e][1,2]thiazin-3-yl)-phenyl-methanone

: 105-35-1
2-chloro-N-ethylacetamide

: 1310459-48-3
2-(3-benzoyl-4-hydroxy-1,1-dioxido-2H-benzo[e][1,2]thiazin-2-yl)-N-ethylacetamide

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 3h;
DOI:10.1016/j.bmcl.2020.127667

Reference yield:

: 1310460-32-2
2-(3-benzoyl-4-hydroxy-1,1-dioxido-2H-benzo[e][1,2]thiazin-2-yl)acetic acid

: 75-04-7,85404-22-4
ethylamine

: 1310459-48-3
2-(3-benzoyl-4-hydroxy-1,1-dioxido-2H-benzo[e][1,2]thiazin-2-yl)-N-ethylacetamide

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 5h;
DOI:10.1248/cpb.59.46

Reference yield:

: 61018-80-2
(4-hydroxy-1,1-dioxo-1,2-dihydro-1λ⁶-benzo[e][1,2]thiazin-3-yl)-phenyl-methanone

: 1310459-48-3
2-(3-benzoyl-4-hydroxy-1,1-dioxido-2H-benzo[e][1,2]thiazin-2-yl)-N-ethylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / ethanol; water / 12 h / 20 °C

2.1: lithium hydroxide / tetrahydrofuran; methanol; water / 5 h

2.2: pH 3 / Cooling with ice

3.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 5 h / 20 °C

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water;
DOI:10.1248/cpb.59.46