Technology Process of (1R,2R)-trans-cyclohex-3-en-1,2-diol
There total 19 articles about (1R,2R)-trans-cyclohex-3-en-1,2-diol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(+/-)-trans-1,2-Diacetoxy-3-cyclohexene;
With
pseudomonas fluorescens lipase;
In
phosphate buffer;
at 38 ℃;
for 40h;
pH=7;
With
sodium methylate;
In
methanol;
at 20 ℃;
for 1h;
DOI:10.1055/s-2001-13406
- Guidance literature:
-
Multi-step reaction with 4 steps
1: imidazole / dimethylformamide / 12 h / 20 °C
2: 23.0 g / aq. m-CPBA / CH2Cl2 / 6 h / 20 °C
3: Et2NLi / diethyl ether; hexane / 17 h / Heating
4: 4.45 g / TBAF / tetrahydrofuran / 14 h / 20 °C
With
1H-imidazole; lithium diethylamide; tetrabutyl ammonium fluoride; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; diethyl ether; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1055/s-2001-13406
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 25.4 g / pyridine / 20 °C
2.1: Pseudomonas Fluorescens Lipase / aq. phosphate buffer / 40 h / 38 °C / pH 7
2.2: 29 percent / MeONa / methanol / 1 h / 20 °C
With
pyridine; pseudomonas fluorescens lipase;
In
phosphate buffer;
DOI:10.1055/s-2001-13406
