ethyl 2-(3-((8-((tert-butoxycarbonyl)(methyl)amino)-4-(3-(((tert-butoxycarbonyl)amino)methyl)azetidin-1-yl)-6-fluoro-9H-pyrimido[4,5-b]indol-2-yl)oxy)-5-cyanophenoxy)acetate

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Chemical Name:ethyl 2-(3-((8-((tert-butoxycarbonyl)(methyl)amino)-4-(3-(((tert-butoxycarbonyl)amino)methyl)azetidin-1-yl)-6-fluoro-9H-pyrimido[4,5-b]indol-2-yl)oxy)-5-cyanophenoxy)acetate
CAS No.:1581683-87-5
Molecular Formula:C₃₆H₄₂FN₇O₈
Molecular Weight:719.77
Hs Code.:

ethyl 2-(3-((8-((tert-butoxycarbonyl)(methyl)amino)-4-(3-(((tert-butoxycarbonyl)amino)methyl)azetidin-1-yl)-6-fluoro-9H-pyrimido[4,5-b]indol-2-yl)oxy)-5-cyanophenoxy)acetate

Synonyms:ethyl 2-(3-((8-((tert-butoxycarbonyl)(methyl)amino)-4-(3-(((tert-butoxycarbonyl)amino)methyl)azetidin-1-yl)-6-fluoro-9H-pyrimido[4,5-b]indol-2-yl)oxy)-5-cyanophenoxy)acetate

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Chemical Property of ethyl 2-(3-((8-((tert-butoxycarbonyl)(methyl)amino)-4-(3-(((tert-butoxycarbonyl)amino)methyl)azetidin-1-yl)-6-fluoro-9H-pyrimido[4,5-b]indol-2-yl)oxy)-5-cyanophenoxy)acetate

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Technology Process of ethyl 2-(3-((8-((tert-butoxycarbonyl)(methyl)amino)-4-(3-(((tert-butoxycarbonyl)amino)methyl)azetidin-1-yl)-6-fluoro-9H-pyrimido[4,5-b]indol-2-yl)oxy)-5-cyanophenoxy)acetate

There total 13 articles about ethyl 2-(3-((8-((tert-butoxycarbonyl)(methyl)amino)-4-(3-(((tert-butoxycarbonyl)amino)methyl)azetidin-1-yl)-6-fluoro-9H-pyrimido[4,5-b]indol-2-yl)oxy)-5-cyanophenoxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 91188-15-7
tert-butyl N-(azetidin-3-ylmethyl)carbamate

: 1581683-86-4
diethyl 2,2'-((((8-((tert-butoxycarbonyl)(methyl)amino)-6-fluoro-9H-pyrimido[4,5-b]indole-2,4-diyl)bis(oxy))bis(3-cyano-5,1-phenylene))bis(oxy))diacetate

: 1581683-87-5
ethyl 2-(3-((8-((tert-butoxycarbonyl)(methyl)amino)-4-(3-(((tert-butoxycarbonyl)amino)methyl)azetidin-1-yl)-6-fluoro-9H-pyrimido[4,5-b]indol-2-yl)oxy)-5-cyanophenoxy)acetate

Guidance literature:: In 1-methyl-pyrrolidin-2-one; at 110 ℃; for 2h;

Reference yield:

: 1581683-76-2
tert-butyl (4-(benzylthio)-6-fluoro-2-((2-(methylthio)pyrimidin-5-yl)oxy)-9H-pyrimido[4,5-b]indol-8-yl)(methyl)carbamate

: 1581683-87-5
ethyl 2-(3-((8-((tert-butoxycarbonyl)(methyl)amino)-4-(3-(((tert-butoxycarbonyl)amino)methyl)azetidin-1-yl)-6-fluoro-9H-pyrimido[4,5-b]indol-2-yl)oxy)-5-cyanophenoxy)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 - 40 °C

2: potassium carbonate / 1-methyl-pyrrolidin-2-one / 1 h / 110 °C

3: 1-methyl-pyrrolidin-2-one / 2 h / 110 °C

With potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In 1-methyl-pyrrolidin-2-one; dichloromethane;

Reference yield:

: 19179-36-3
3,5-dihydroxycyanobenzene

: 1581683-87-5
ethyl 2-(3-((8-((tert-butoxycarbonyl)(methyl)amino)-4-(3-(((tert-butoxycarbonyl)amino)methyl)azetidin-1-yl)-6-fluoro-9H-pyrimido[4,5-b]indol-2-yl)oxy)-5-cyanophenoxy)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 2 h / 80 °C

2: potassium carbonate / 1-methyl-pyrrolidin-2-one / 1 h / 110 °C

3: 1-methyl-pyrrolidin-2-one / 2 h / 110 °C

With potassium carbonate; In 1-methyl-pyrrolidin-2-one;