{5-[4-(1-aminocyclobutyl)phenyl]-6-phenyl-2-pyridine-2-yl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}tert-butylamine

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Chemical Name:{5-[4-(1-aminocyclobutyl)phenyl]-6-phenyl-2-pyridine-2-yl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}tert-butylamine
CAS No.:1355239-74-5
Molecular Formula:C₃₀H₃₁N₇
Molecular Weight:489.623
Hs Code.:

Synonyms:{5-[4-(1-aminocyclobutyl)phenyl]-6-phenyl-2-pyridine-2-yl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}tert-butylamine

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Chemical Property of {5-[4-(1-aminocyclobutyl)phenyl]-6-phenyl-2-pyridine-2-yl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}tert-butylamine

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Technology Process of {5-[4-(1-aminocyclobutyl)phenyl]-6-phenyl-2-pyridine-2-yl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}tert-butylamine

There total 6 articles about {5-[4-(1-aminocyclobutyl)phenyl]-6-phenyl-2-pyridine-2-yl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}tert-butylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.2%

: 1355240-56-0
{1-[4-(7-tert-butylamino-6-phenyl-2-pyridine-2-yl-[1,2,4]triazolo[1,5-a]pyrimidin-5-yl)phenyl]cyclobutyl}carbamic acid tert-butyl ester

: 1355239-74-5
{5-[4-(1-aminocyclobutyl)phenyl]-6-phenyl-2-pyridine-2-yl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}tert-butylamine

Guidance literature:: {1-[4-(7-tert-butylamino-6-phenyl-2-pyridine-2-yl-[1,2,4]triazolo[1,5-a]pyrimidin-5-yl)phenyl]cyclobutyl}carbamic acid tert-butyl ester; With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 6h;

In methanol; dichloromethane; pH=9;

Reference yield:

: 1032350-06-3
tert-butyl (1-(4-bromophenyl)cyclobutyl)carbamate

: 1355239-74-5
{5-[4-(1-aminocyclobutyl)phenyl]-6-phenyl-2-pyridine-2-yl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}tert-butylamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran / Reflux

2.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane; water / 18 h / 90 °C / Inert atmosphere

3.1: hydrogenchloride / 1,4-dioxane / 6 h / 20 °C

3.2: amine silicagel / pH 9

With hydrogenchloride; potassium acetate; sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; water;

Reference yield:

: 1094218-30-0
1-(4-bromophenyl)cyclobutanamine

: 1355239-74-5
{5-[4-(1-aminocyclobutyl)phenyl]-6-phenyl-2-pyridine-2-yl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}tert-butylamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C / Inert atmosphere

2.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran / Reflux

3.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane; water / 18 h / 90 °C / Inert atmosphere

4.1: hydrogenchloride / 1,4-dioxane / 6 h / 20 °C

4.2: amine silicagel / pH 9

With hydrogenchloride; potassium acetate; sodium carbonate; N-ethyl-N,N-diisopropylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; water;