tert-butyl-(5-chloro-6-phenyl-2-pyridine-2-yl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)amine

Base Information

Chemical Name:tert-butyl-(5-chloro-6-phenyl-2-pyridine-2-yl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)amine
CAS No.:1355240-55-9
Molecular Formula:C₂₀H₁₉ClN₆
Molecular Weight:378.864
Hs Code.:

Synonyms:tert-butyl-(5-chloro-6-phenyl-2-pyridine-2-yl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)amine

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Chemical Property of tert-butyl-(5-chloro-6-phenyl-2-pyridine-2-yl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)amine

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Technology Process of tert-butyl-(5-chloro-6-phenyl-2-pyridine-2-yl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)amine

There total 1 articles about tert-butyl-(5-chloro-6-phenyl-2-pyridine-2-yl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.8%

: 1240469-59-3
5,7-dichloro-6-phenyl-2-pyridine-2-yl-[1,2,4]triazolo[1,5-a]pyrimidine

: 75-64-9
tert-butylamine

: 1355240-55-9
tert-butyl-(5-chloro-6-phenyl-2-pyridine-2-yl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)amine

Guidance literature:: In N,N-dimethyl-formamide; at 100 ℃; for 0.333333h; microwave irradiation;

Reference yield:

: 1032528-06-5
{1-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-cyclobutyl}-carbamic acid tert.-butyl ester

: 1355240-55-9
tert-butyl-(5-chloro-6-phenyl-2-pyridine-2-yl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)amine

: 1355240-56-0
{1-[4-(7-tert-butylamino-6-phenyl-2-pyridine-2-yl-[1,2,4]triazolo[1,5-a]pyrimidin-5-yl)phenyl]cyclobutyl}carbamic acid tert-butyl ester

Guidance literature:: With sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,2-dimethoxyethane; water; at 90 ℃; for 18h; Inert atmosphere;

Reference yield:

: 1032528-06-5
{1-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-cyclobutyl}-carbamic acid tert.-butyl ester

: 1355240-55-9
tert-butyl-(5-chloro-6-phenyl-2-pyridine-2-yl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)amine

: 1355239-74-5
{5-[4-(1-aminocyclobutyl)phenyl]-6-phenyl-2-pyridine-2-yl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}tert-butylamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane; water / 18 h / 90 °C / Inert atmosphere

2.1: hydrogenchloride / 1,4-dioxane / 6 h / 20 °C

2.2: amine silicagel / pH 9

With hydrogenchloride; sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; 1,2-dimethoxyethane; water;