1-(5-(1-(4-chlorophenyl)-1H-pyrazol-4-yl)pent-4-ynyl)-4-phenylpiperazine

Base Information

Chemical Name:1-(5-(1-(4-chlorophenyl)-1H-pyrazol-4-yl)pent-4-ynyl)-4-phenylpiperazine
CAS No.:1449038-94-1
Molecular Formula:C₂₄H₂₅ClN₄
Molecular Weight:404.942
Hs Code.:

Synonyms:1-(5-(1-(4-chlorophenyl)-1H-pyrazol-4-yl)pent-4-ynyl)-4-phenylpiperazine

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Chemical Property of 1-(5-(1-(4-chlorophenyl)-1H-pyrazol-4-yl)pent-4-ynyl)-4-phenylpiperazine

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Technology Process of 1-(5-(1-(4-chlorophenyl)-1H-pyrazol-4-yl)pent-4-ynyl)-4-phenylpiperazine

There total 3 articles about 1-(5-(1-(4-chlorophenyl)-1H-pyrazol-4-yl)pent-4-ynyl)-4-phenylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 92-54-6
4-phenyl-1-piperazine

: 1449038-93-0
5-(1-(4-chlorophenyl)-1H-pyrazol-4-yl)pent-4-ynyl 4-toluenesulfonate

: 1449038-94-1
1-(5-(1-(4-chlorophenyl)-1H-pyrazol-4-yl)pent-4-ynyl)-4-phenylpiperazine

Guidance literature:: With lithium carbonate; In acetonitrile; at 80 ℃; for 20h; Inert atmosphere;
DOI:10.1016/j.ejmech.2013.05.027

Reference yield:

: 25419-86-7
1-(4-chlorophenyl)-1H-pyrazole

: 1449038-94-1
1-(5-(1-(4-chlorophenyl)-1H-pyrazol-4-yl)pent-4-ynyl)-4-phenylpiperazine

Guidance literature:: Multi-step reaction with 4 steps

1.1: dihydrogen peroxide; iodine / water; acetonitrile / 24 h / 20 °C

2.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / 1,4-dioxane / 12 h / 0 - 20 °C / Inert atmosphere

3.1: potassium hydroxide / 0.08 h / 20 °C

3.2: 0.33 h / 20 °C

4.1: lithium carbonate / acetonitrile / 20 h / 80 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; dihydrogen peroxide; iodine; lithium carbonate; triethylamine; potassium hydroxide; In 1,4-dioxane; water; acetonitrile; 2.1: |Sonogashira Cross-Coupling;
DOI:10.1016/j.ejmech.2013.05.027

Reference yield:

: 1449038-89-4
1-(4-chlorophenyl)-4-iodo-1H-pyrazole

: 1449038-94-1
1-(5-(1-(4-chlorophenyl)-1H-pyrazol-4-yl)pent-4-ynyl)-4-phenylpiperazine

Guidance literature:: Multi-step reaction with 3 steps

1.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / 1,4-dioxane / 12 h / 0 - 20 °C / Inert atmosphere

2.1: potassium hydroxide / 0.08 h / 20 °C

2.2: 0.33 h / 20 °C

3.1: lithium carbonate / acetonitrile / 20 h / 80 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; lithium carbonate; triethylamine; potassium hydroxide; In 1,4-dioxane; acetonitrile; 1.1: |Sonogashira Cross-Coupling;
DOI:10.1016/j.ejmech.2013.05.027