25419-86-7

Basic information

• Product Name: 1-(4-Chlorophenyl)-1H-pyrazole
• Synonyms: 1-(4-Chlorophenyl)-1H-pyrazole;1-(4-Chlorophenyl)-1H-pyrazol;1-(4-CHLOROPHENYL)PYRAZOLE
• CAS NO: 25419-86-7
• Molecular Formula: C₉H₇ClN₂
• Molecular Weight: 178.62
• Mol File: 25419-86-7.mol
• Article Data: 32

Chemical Properties

• Melting Point: 52 °C
• Boiling Point: 108-110 °C(Press: 0.5 Torr)
• Appearance: /
• Density: 1.23±0.1 g/cm3(Predicted)
• PKA: -0.12±0.10(Predicted)
• CAS DataBase Reference: 1-(4-Chlorophenyl)-1H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-Chlorophenyl)-1H-pyrazole(25419-86-7)
• EPA Substance Registry System: 1-(4-Chlorophenyl)-1H-pyrazole(25419-86-7)

Safety Data

• Hazardous Substances Data: 25419-86-7(Hazardous Substances Data)

Usage

General Description

1-(4-Chlorophenyl)-1H-pyrazole, also known as CPP or 4-CPP, is a chemical compound with the molecular formula C9H7ClN2. It is a pyrazole derivative that is commonly used in the research and development of pharmaceuticals and agrochemicals. 1-(4-Chlorophenyl)-1H-pyrazole is a potent and selective inhibitor of the enzyme cyclooxygenase-2 (COX-2), which is involved in the inflammatory response. As a result, CPP has potential applications in the treatment of inflammatory conditions such as arthritis, as well as in cancer therapy and neurodegenerative diseases. Its structure and properties make it an important molecule for the study of structure-activity relationships in drug design and discovery.

Upstream product

• 288-13-1 NH-pyrazole 
• 106-39-8 bromochlorobenzene 
• 829-31-2 3-(4-chlorophenyl)sydnone 
• 79-10-7 acrylic acid 
• 352-33-0 1-Chloro-4-fluorobenzene 
• 106-47-8 4-chloro-aniline 
• 673-41-6 p-chlorobenzenediazonium tetrafluoroborate 
• 102-52-3 malonaldehydebis(dimethylacetal) 
• 1073-70-7 4-chlorophenylhydrazine hydrochloride 
• 106-46-7 para-dichlorobenzene 
• 637-87-6 1-Chloro-4-iodobenzene 
• 1073-69-4 N-4-chlorophenylhydrazine 

Downstream Products

• 63874-99-7 1-(4-chlorophenyl)-1H-pyrazole-4-carbaldehyde 
• 138907-80-9 1-(4-chlorophenyl)-1H-pyrazole-4-carboxylic acid 
• 1410806-35-7 1-[1-(4-Chloro-phenyl)-1H-pyrazol-4-yl]-2-piperidin-1-yl-ethanone 
• 1410806-73-3 2-chloro-1-[1-(4-chloro-phenyl)-1H-pyrazol-4-yl]-ethanone 
• 1283289-77-9 C₁₀H₆Cl₂N₂O 
• 851180-84-2 (1-(4-chlorophenyl)-1H-pyrazol-4-yl)methanol 
• 1449038-93-0 5-(1-(4-chlorophenyl)-1H-pyrazol-4-yl)pent-4-ynyl 4-toluenesulfonate 
• 1449038-82-7 LASSBio-1762 
• 1449038-81-6 LASSBio-1635 
• 1449038-80-5 LASSBio-1528 
• 1449038-92-9 5-(1-(4-chlorophenyl)-1H-pyrazol-4-yl)pent-4-yn-1-ol 
• 1449038-91-8 1-(4-(1-(4-chlorophenyl)-1H-pyrazol-4-yl)but-3-ynyl)-4-phenylpiperazine 
• 1449038-90-7 1-(3-(1-(4-chlorophenyl)-1H-pyrazol-4-yl)prop-2-ynyl)-4-phenylpiperazine 
• 1449038-89-4 1-(4-chlorophenyl)-4-iodo-1H-pyrazole 

Relevant articles and documents

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Organophotochemical SNAr Reactions of Mildly Electron-Poor Fluoroarenes

C–F functionalization of arenes with a range of alcohol and pyrazole nucleophiles has been achieved without the need for metal catalysts or highly electron-poor substrates. Treatment of fluoroarenes with alcohols or pyrazoles and DDQ under irradiation by blue LED light provides the corresponding substituted products. The procedure is complementary to classical SNAr chemistry which generally requires basic reaction conditions and high temperatures, and provides products under non-basic conditions at ≈ 40 °C.

Efficient copper-catalyzed N-arylation of NH-containing heterocycles and sulfonamides with arenediazonium tetrafluoroborates

A practical copper-catalyzed N-arylation of NH-containing heterocycles with arenediazonium tetrafluoroborates has been developed using CuCl as catalyst and K2CO3 as additive under ligand-free conditions. This reaction system has wide substrate scope including imides, 1H-pyrazole, 1H-tetrazoles, 1,2-benzisothiazol-3(2H)-one, and related sulfonamides and gives moderate to excellent yields (up to 95%) of the desired products. This strategy is very general, simple, environmentally friendly, and tolerant of oxygen.