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1-(4-Chlorophenyl)-1H-pyrazole, also known as CPP or 4-CPP, is a chemical compound with the molecular formula C9H7ClN2. It is a pyrazole derivative that is commonly used in the research and development of pharmaceuticals and agrochemicals. 1-(4-Chlorophenyl)-1H-pyrazole is a potent and selective inhibitor of the enzyme cyclooxygenase-2 (COX-2), which plays a significant role in the inflammatory response.

25419-86-7

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25419-86-7 Usage

Uses

Used in Pharmaceutical Research and Development:
1-(4-Chlorophenyl)-1H-pyrazole is used as a research compound for the development of new pharmaceuticals. Its potent and selective inhibition of COX-2 makes it a valuable tool in studying the structure-activity relationships in drug design and discovery.
Used in Treatment of Inflammatory Conditions:
In the medical field, 1-(4-Chlorophenyl)-1H-pyrazole is used as an anti-inflammatory agent for the treatment of conditions such as arthritis. Its COX-2 inhibiting properties help in reducing inflammation and alleviating pain associated with these conditions.
Used in Cancer Therapy:
1-(4-Chlorophenyl)-1H-pyrazole is also used as a potential therapeutic agent in cancer treatment. Its COX-2 inhibiting properties may contribute to the suppression of tumor growth and the modulation of cancer-related pathways.
Used in Agrochemical Research:
In the agrochemical industry, 1-(4-Chlorophenyl)-1H-pyrazole is used as a research compound for the development of new agrochemical products. Its structure and properties make it an important molecule for understanding the interactions between chemicals and biological systems in agriculture.

Check Digit Verification of cas no

The CAS Registry Mumber 25419-86-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,5,4,1 and 9 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 25419-86:
(7*2)+(6*5)+(5*4)+(4*1)+(3*9)+(2*8)+(1*6)=117
117 % 10 = 7
So 25419-86-7 is a valid CAS Registry Number.

25419-86-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(4-chlorophenyl)-1H-pyrazole

1.2 Other means of identification

Product number -
Other names 1-(4-chlorophenyl)pyrazole

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:25419-86-7 SDS

25419-86-7Relevant academic research and scientific papers

Induction of apoptosis in Ehrlich ascites tumour cells via p53 activation by a novel small-molecule MDM2 inhibitor – LQFM030

da Mota, Mariana F.,Cortez, Alane P.,Benfica, Polyana L.,Rodrigues, Bruna dos S.,Castro, Thalyta F.,Macedo, Larissa M.,Castro, Carlos H.,Li?o, Luciano M.,de Carvalho, Flávio S.,Romeiro, Luiz A. S.,Menegatti, Ricardo,Verli, Hugo,Villavicencio, Bianca,Valadares, Marize C.

, p. 1143 - 1159 (2016)

Objective: The activation of the p53 pathway through the inhibition of MDM2 has been proposed as a novel therapeutic strategy against tumours. A series of cis-imidazoline analogues, termed nutlins, were reported to displace the recombinant p53 protein fro

Design, synthesis and pharmacological profile of novel dopamine D2 receptor ligands

Menegatti, Ricardo,Cunha, Anna C.,Ferreira, Vitor F.,Perreira, Edna F. R.,El-Nabawi, Ahmed,Eldefrawi, Amira T.,Albuquerque, Edson X.,Neves, Gilda,Rates, Stela M. K.,Fraga, Carlos A. M.,Barreiro, Eliezer J.

, p. 4807 - 4813 (2003)

The present study describes the synthesis and pharmacological profile of three novel heterocyclic compounds originally designed, on the basis of bioisosterism, as dopamine D2 receptor ligands: 1-[1-(4-chlorophenyl)-1H-pyrazol-4-ylmethyl]-4-phenyl-piperazi

The novel piperazine-containing compound LQFM018: Necroptosis cell death mechanisms, dopamine D4 receptor binding and toxicological assessment

Costa, Fabiana Bettanin,Cortez, Alane P.,de ávila, Renato Ivan,de Carvalho, Flávio S.,Andrade, Wanessa M.,da Cruz, Andrezza F.,Reis, Karinna B.,Menegatti, Ricardo,Li?o, Luciano M.,Romeiro, Luiz Ant?nio S.,No?l, Fran?ois,Fraga, Carlos Alberto M.,Barreiro, Eliezer J.,Sanz, Germán,Rodrigues, Marcella F.,Vaz, Boniek G.,Valadares, Marize Campos

, p. 481 - 493 (2018)

Piperazine is a promising scaffold for drug development due to its broad spectrum of biological activities. Based on this, the new piperazine-containing compound LQFM018 (2) [ethyl 4-((1-(4-chlorophenyl)-1H-pyrazol-4-yl)methyl)piperazine-1-carboxylate] wa

Copper pyrithione (CuPT)-catalyzed/mediated amination and thioarylation of (hetero)aryl halides: A competition

Cao, Ningtao,Song, Bao,Xie, Jianwei,Zhang, Jie

, (2021/11/08)

A facile method for the synthesis of N-arylheterocycles and di(hetero)aryl sulfides under mild condition is described. In these transformations, copper pyrithione (CuPT) was used as the copper catalyst for C─N coupling, while served as catalyst and coupled partner for C─S coupling with high yields and broad substrate tolerance. The S-arylation process was also utilized for the construction of valuable bioactive 2-sulfonylpyridine 1-oxide derivatives.

Organophotochemical SNAr Reactions of Mildly Electron-Poor Fluoroarenes

Burton, Jonathan W.,Genovino, Julien,Lian, Yajing,Monck, Nat,Sheridan, Thomas,Yayla, Hatice G.

supporting information, p. 2766 - 2770 (2020/05/18)

C–F functionalization of arenes with a range of alcohol and pyrazole nucleophiles has been achieved without the need for metal catalysts or highly electron-poor substrates. Treatment of fluoroarenes with alcohols or pyrazoles and DDQ under irradiation by blue LED light provides the corresponding substituted products. The procedure is complementary to classical SNAr chemistry which generally requires basic reaction conditions and high temperatures, and provides products under non-basic conditions at ≈ 40 °C.

Ruthenium-Catalyzed ortho- And meta-H/D Exchange of Arenes

Zhao, Liang-Liang,Liu, Wei,Zhang, Zengyu,Zhao, Hongyan,Wang, Qi,Yan, Xiaoyu

supporting information, p. 10023 - 10027 (2019/12/24)

Ruthenium-catalyzed aromatic H/D exchange in [D4]acetic acid has been developed. By using N-heteroarenes as directing groups, both ortho and meta positions are selectively deuterated with high levels of D incorporation. Moreover, this strategy provides an alternative way to achieve meta-C-H activation.

Efficient copper-catalyzed N-arylation of NH-containing heterocycles and sulfonamides with arenediazonium tetrafluoroborates

Ouyang, Yu-Qing,Yang, Zhen-Hua,Chen, Zhong-Hui,Zhao, Sheng-Yin

, p. 771 - 778 (2017/04/06)

A practical copper-catalyzed N-arylation of NH-containing heterocycles with arenediazonium tetrafluoroborates has been developed using CuCl as catalyst and K2CO3 as additive under ligand-free conditions. This reaction system has wide substrate scope including imides, 1H-pyrazole, 1H-tetrazoles, 1,2-benzisothiazol-3(2H)-one, and related sulfonamides and gives moderate to excellent yields (up to 95%) of the desired products. This strategy is very general, simple, environmentally friendly, and tolerant of oxygen.

PYRAZOLYL PYRIMIDINAMINE COMPOUND AND APPLICATION THEREOF

-

Paragraph 0366; 0367, (2016/12/01)

Disclosed are pyrazolyl pyrimidinamine compounds with structures as shown in Formula I: The definitions of each of the substituents can be seen in the description. The compounds of present invention have a broad spectrum of bactericidal, insecticidal and acaricidal activity, and have good control effect on downy mildew of cucumber, powdery mildew of wheat, corn rust, anthracnosis of cucumber and the like, and especially have better control effect on downy mildew of cucumber, powdery mildew of wheat and anthracnosis of cucumber. The compounds of present invention also show good insecticidal activity, part of the compounds, at very low doses, have excellent control effect on diseases caused by Plutella xylostella, armyworm, Myzus persicae, Tetranychus cinnabarinus etc.

Facile Synthesis of 1-Arylpyrazoles

Yang, Yiwen,Kuang, Chunxiang

supporting information, p. 2281 - 2284 (2015/08/03)

A convenient and transition-metal-free synthesis of 1-arylpyrazoles that involves the cycloaddition of 3-arylsydnones and acrylic acid is presented. The process proceeds smoothly to obtain the target products with moderate to high yields.

Aromatic N-arylations catalyzed by copper-anchored porous zinc-based metal-organic framework under heterogeneous conditions

Maity, Tanmoy,Saha, Debraj,Koner, Subratanath

, p. 2373 - 2383 (2014/08/18)

A highly porous Zn-based metal-organic framework (MOF) IRMOF-3 was covalently decorated with pyridine-2-aldehyde. The free amine group of IRMOF-3 upon condensation with pyridine-2-aldehyde affords a bidentate Schiff-base moiety in the porous matrix. The Schiff base moieties are availed to anchor copper(II) ions to display the catalyst's utility towards catalytic reactions. The catalyst was characterized by UV/Vis and IR spectroscopy, powder XRD spectrometry, SEM energy-dispersive X-ray spectrometry, and nitrogen sorption measurements. The catalyst exhibits excellent activity in catalyzing the N-arylation reaction of nitrogen-containing heterocycles with aryl bromides in DMSO medium, under mild condition (90°C) in the presence of Cs 2CO3. The porous catalyst demonstrates size selectivity towards substrate as a result of the presence of active sites inside the pores of the MOF. The anchored complex seems to be not leached or decomposed during the catalytic reactions up to five successive catalytic cycles, demonstrating practical advantages over homogeneous catalysis.

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