25419-86-7

Usage

Uses

Used in Pharmaceutical Research and Development:
1-(4-Chlorophenyl)-1H-pyrazole is used as a research compound for the development of new pharmaceuticals. Its potent and selective inhibition of COX-2 makes it a valuable tool in studying the structure-activity relationships in drug design and discovery.
Used in Treatment of Inflammatory Conditions:
In the medical field, 1-(4-Chlorophenyl)-1H-pyrazole is used as an anti-inflammatory agent for the treatment of conditions such as arthritis. Its COX-2 inhibiting properties help in reducing inflammation and alleviating pain associated with these conditions.
Used in Cancer Therapy:
1-(4-Chlorophenyl)-1H-pyrazole is also used as a potential therapeutic agent in cancer treatment. Its COX-2 inhibiting properties may contribute to the suppression of tumor growth and the modulation of cancer-related pathways.
Used in Agrochemical Research:
In the agrochemical industry, 1-(4-Chlorophenyl)-1H-pyrazole is used as a research compound for the development of new agrochemical products. Its structure and properties make it an important molecule for understanding the interactions between chemicals and biological systems in agriculture.

Upstream product

• 288-13-1 NH-pyrazole 
• 106-39-8 bromochlorobenzene 
• 637-87-6 1-Chloro-4-iodobenzene 
• 106-46-7 para-dichlorobenzene 
• 352-33-0 1-Chloro-4-fluorobenzene 
• 106-47-8 4-chloro-aniline 
• 673-41-6 p-chlorobenzenediazonium tetrafluoroborate 
• 102-52-3 malonaldehydebis(dimethylacetal) 
• 1073-70-7 4-chlorophenylhydrazine hydrochloride 
• 829-31-2 3-(4-chlorophenyl)sydnone 
• 79-10-7 acrylic acid 
• 1073-69-4 N-4-chlorophenylhydrazine 

Downstream Products

• 63874-99-7 1-(4-chlorophenyl)-1H-pyrazole-4-carbaldehyde 
• 1350896-23-9 1-{2-[(E)-2-(butyloxycarbonyl)ethenyl](p-chlorophenyl)}-1H-pyrazole 
• 1417034-42-4 1-[2,6-bis[(1E)-1,2-diphenylethenyl]-4-chlorophenyl]pyrazole 
• 1436430-00-0 diethyl 2-(5-chloro-2-(1H-pyrazol-1-yl)phenyl)malonate 
• 851180-84-2 (1-(4-chlorophenyl)-1H-pyrazol-4-yl)methanol 

Relevant academic research and scientific papers

Induction of apoptosis in Ehrlich ascites tumour cells via p53 activation by a novel small-molecule MDM2 inhibitor – LQFM030

Objective: The activation of the p53 pathway through the inhibition of MDM2 has been proposed as a novel therapeutic strategy against tumours. A series of cis-imidazoline analogues, termed nutlins, were reported to displace the recombinant p53 protein fro

Design, synthesis and pharmacological profile of novel dopamine D2 receptor ligands

The present study describes the synthesis and pharmacological profile of three novel heterocyclic compounds originally designed, on the basis of bioisosterism, as dopamine D2 receptor ligands: 1-[1-(4-chlorophenyl)-1H-pyrazol-4-ylmethyl]-4-phenyl-piperazi

The novel piperazine-containing compound LQFM018: Necroptosis cell death mechanisms, dopamine D4 receptor binding and toxicological assessment

Piperazine is a promising scaffold for drug development due to its broad spectrum of biological activities. Based on this, the new piperazine-containing compound LQFM018 (2) [ethyl 4-((1-(4-chlorophenyl)-1H-pyrazol-4-yl)methyl)piperazine-1-carboxylate] wa

Copper pyrithione (CuPT)-catalyzed/mediated amination and thioarylation of (hetero)aryl halides: A competition

A facile method for the synthesis of N-arylheterocycles and di(hetero)aryl sulfides under mild condition is described. In these transformations, copper pyrithione (CuPT) was used as the copper catalyst for C─N coupling, while served as catalyst and coupled partner for C─S coupling with high yields and broad substrate tolerance. The S-arylation process was also utilized for the construction of valuable bioactive 2-sulfonylpyridine 1-oxide derivatives.

Organophotochemical SNAr Reactions of Mildly Electron-Poor Fluoroarenes

C–F functionalization of arenes with a range of alcohol and pyrazole nucleophiles has been achieved without the need for metal catalysts or highly electron-poor substrates. Treatment of fluoroarenes with alcohols or pyrazoles and DDQ under irradiation by blue LED light provides the corresponding substituted products. The procedure is complementary to classical SNAr chemistry which generally requires basic reaction conditions and high temperatures, and provides products under non-basic conditions at ≈ 40 °C.

Ruthenium-Catalyzed ortho- And meta-H/D Exchange of Arenes

Ruthenium-catalyzed aromatic H/D exchange in [D4]acetic acid has been developed. By using N-heteroarenes as directing groups, both ortho and meta positions are selectively deuterated with high levels of D incorporation. Moreover, this strategy provides an alternative way to achieve meta-C-H activation.

Efficient copper-catalyzed N-arylation of NH-containing heterocycles and sulfonamides with arenediazonium tetrafluoroborates

A practical copper-catalyzed N-arylation of NH-containing heterocycles with arenediazonium tetrafluoroborates has been developed using CuCl as catalyst and K2CO3 as additive under ligand-free conditions. This reaction system has wide substrate scope including imides, 1H-pyrazole, 1H-tetrazoles, 1,2-benzisothiazol-3(2H)-one, and related sulfonamides and gives moderate to excellent yields (up to 95%) of the desired products. This strategy is very general, simple, environmentally friendly, and tolerant of oxygen.

PYRAZOLYL PYRIMIDINAMINE COMPOUND AND APPLICATION THEREOF

Disclosed are pyrazolyl pyrimidinamine compounds with structures as shown in Formula I: The definitions of each of the substituents can be seen in the description. The compounds of present invention have a broad spectrum of bactericidal, insecticidal and acaricidal activity, and have good control effect on downy mildew of cucumber, powdery mildew of wheat, corn rust, anthracnosis of cucumber and the like, and especially have better control effect on downy mildew of cucumber, powdery mildew of wheat and anthracnosis of cucumber. The compounds of present invention also show good insecticidal activity, part of the compounds, at very low doses, have excellent control effect on diseases caused by Plutella xylostella, armyworm, Myzus persicae, Tetranychus cinnabarinus etc.

Facile Synthesis of 1-Arylpyrazoles

A convenient and transition-metal-free synthesis of 1-arylpyrazoles that involves the cycloaddition of 3-arylsydnones and acrylic acid is presented. The process proceeds smoothly to obtain the target products with moderate to high yields.

3-(Diphenylphosphino)propanoic acid: An efficient ligand for the Cu-catalyzed N-arylation of imidazoles and 1H-pyrazole with aryl halides

3-(Diphenylphosphino)propanoic acid (L2) has proved to be an efficient ligand for the copper-catalyzed CN coupling reactions. N-arylation of imidazoles with aryl iodides catalyzed by CuCl/L2 was smoothly carried out in DMSO at 100 °C with a yield up to 98%. N-arylation of 1H-pyrazole with aryl iodides and bromides catalyzed by Cu(OAc)2/L2 in 1,4-dioxane also gave the corresponding products with yields of 40%-98%.