Technology Process of 1,1-dimethylethyl cyclopropyl{[2,3-dichloro-5-(cyanomethyl)phenyl]methyl}carbamate
There total 10 articles about 1,1-dimethylethyl cyclopropyl{[2,3-dichloro-5-(cyanomethyl)phenyl]methyl}carbamate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium iodide;
In
dimethyl sulfoxide;
at 20 ℃;
for 3h;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: magnesium sulfate / dichloromethane / 20 °C
2.1: magnesium sulfate / dichloromethane / 20 °C
3.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 48 h / 20 °C
4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 20 °C
5.1: sodium carbonate; triphenylphosphine / palladium diacetate / propan-1-ol; water; N,N-dimethyl-formamide / 18 h / 90 °C / Inert atmosphere of nitrogen
6.1: ozone / dichloromethane / -78 °C
6.2: 3 h / -78 - 20 °C
7.1: sodium tetrahydroborate / methanol / 2 h / 0 °C
8.1: N-ethyl-N,N-diisopropylamine / 0 - 20 °C
9.1: sodium iodide / dimethyl sulfoxide / 3 h / 20 °C
With
sodium tetrahydroborate; sodium carbonate; magnesium sulfate; ozone; N-ethyl-N,N-diisopropylamine; triphenylphosphine; sodium iodide;
palladium diacetate;
In
tetrahydrofuran; methanol; propan-1-ol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
5.1: Suzuki Coupling;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 48 h / 20 °C
2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 20 °C
3.1: sodium carbonate; triphenylphosphine / palladium diacetate / propan-1-ol; water; N,N-dimethyl-formamide / 18 h / 90 °C / Inert atmosphere of nitrogen
4.1: ozone / dichloromethane / -78 °C
4.2: 3 h / -78 - 20 °C
5.1: sodium tetrahydroborate / methanol / 2 h / 0 °C
6.1: N-ethyl-N,N-diisopropylamine / 0 - 20 °C
7.1: sodium iodide / dimethyl sulfoxide / 3 h / 20 °C
With
sodium tetrahydroborate; sodium carbonate; ozone; N-ethyl-N,N-diisopropylamine; triphenylphosphine; sodium iodide;
palladium diacetate;
In
tetrahydrofuran; methanol; propan-1-ol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
3.1: Suzuki Coupling;
