methyl 2-(2-(2-chloro-5-fluorobenzylcarbamothioyl)hydrazono)propanoate

Base Information

Chemical Name:methyl 2-(2-(2-chloro-5-fluorobenzylcarbamothioyl)hydrazono)propanoate
CAS No.:1312954-61-2
Molecular Formula:C₁₂H₁₃ClFN₃O₂S
Molecular Weight:317.772
Hs Code.:

Synonyms:methyl 2-(2-(2-chloro-5-fluorobenzylcarbamothioyl)hydrazono)propanoate

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Chemical Property of methyl 2-(2-(2-chloro-5-fluorobenzylcarbamothioyl)hydrazono)propanoate

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Technology Process of methyl 2-(2-(2-chloro-5-fluorobenzylcarbamothioyl)hydrazono)propanoate

There total 6 articles about methyl 2-(2-(2-chloro-5-fluorobenzylcarbamothioyl)hydrazono)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1312954-60-1
N-(2-chloro-5-fluorobenzyl)hydrazinecarbothioamide

: 127-17-3
2-oxo-propionic acid

: 1312954-61-2
methyl 2-(2-(2-chloro-5-fluorobenzylcarbamothioyl)hydrazono)propanoate

Guidance literature:: sulfuric acid; In methanol; for 15h; Reflux;

Reference yield:

: 2252-50-8
2-chloro-5-fluoro-benzoic acid

: 1312954-61-2
methyl 2-(2-(2-chloro-5-fluorobenzylcarbamothioyl)hydrazono)propanoate

Guidance literature:: Multi-step reaction with 6 steps

1: sulfuric acid / 24 h / Reflux

2: sodium tetrahydroborate; methanol / 1 h / 20 °C

3: phosphorus tribromide / 1,2-dimethoxyethane / 3 h / 0 - 20 °C

4: sodium iodide / N,N-dimethyl-formamide / 18 h / 90 °C / Inert atmosphere

5: hydrazine hydrate / 1,4-dioxane / 2 h / 0 - 20 °C

6: sulfuric acid / methanol / 15 h / Reflux

With methanol; sodium tetrahydroborate; hydrazine hydrate; sulfuric acid; phosphorus tribromide; sodium iodide; sulfuric acid; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; N,N-dimethyl-formamide;

Reference yield:

: 81778-09-8
1-(bromomethyl)-2-chloro-5-fluorobenzene

: 1312954-61-2
methyl 2-(2-(2-chloro-5-fluorobenzylcarbamothioyl)hydrazono)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium iodide / N,N-dimethyl-formamide / 18 h / 90 °C / Inert atmosphere

2: hydrazine hydrate / 1,4-dioxane / 2 h / 0 - 20 °C

3: sulfuric acid / methanol / 15 h / Reflux

With hydrazine hydrate; sodium iodide; sulfuric acid; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;