1-((2-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho[2,1-d]thiazol-7-yl)methyl)azetidine-3-carboxylic acid TFA

Base Information

• Chemical Name: 1-((2-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho[2,1-d]thiazol-7-yl)methyl)azetidine-3-carboxylic acid TFA
• CAS No.: 1307810-22-5
• Molecular Formula: C₂HF₃O₂*C₂₆H₂₀F₃N₃O₃S
• Molecular Weight: 625.548
• Mol file: 1307810-22-5.mol

Synonyms:1-((2-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho[2,1-d]thiazol-7-yl)methyl)azetidine-3-carboxylic acid TFA

Chemical Property of 1-((2-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho[2,1-d]thiazol-7-yl)methyl)azetidine-3-carboxylic acid TFA

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-((2-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho[2,1-d]thiazol-7-yl)methyl)azetidine-3-carboxylic acid TFA

There total 6 articles about 1-((2-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho[2,1-d]thiazol-7-yl)methyl)azetidine-3-carboxylic acid TFA which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 2.279%

1-((2-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho[2,1-d]thiazol-7-yl)methyl)azetidine-3-carboxylic acid, TFA salt (1307810-21-4) + trifluoroacetic acid (76-05-1) → 1-((2-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho[2,1-d]thiazol-7-yl)methyl)azetidine-3-carboxylic acid TFA (1307810-22-5)

Guidance literature:

In methanol; water;

Reference yield:

3-phenyl-4-(trifluoromethyl)-5-(7-vinyl-4,5-dihydronaphtho-[2,1-d]thiazol-2-yl)isoxazole (1307813-35-9) → 1-((2-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho[2,1-d]thiazol-7-yl)methyl)azetidine-3-carboxylic acid TFA (1307810-22-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: osmium(VIII) oxide; sodium periodate / butan-1-ol; water; tetrahydrofuran / 1.5 h / 20 °C

2.1: methanol / acetic acid / 1,2-dichloro-ethane / 1 h / 80 °C

2.2: 1 h / 20 °C

3.1: water; methanol

With methanol; sodium periodate; osmium(VIII) oxide; acetic acid; In tetrahydrofuran; methanol; water; 1,2-dichloro-ethane; butan-1-ol;

Reference yield:

2-(3-phenyl-4-(trifluoromethyl )isoxazol-5-yl)-4,5-dihydronaphtho[2,1-d]thiazole-7-carbaldehyde (1307813-36-0) → 1-((2-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho[2,1-d]thiazol-7-yl)methyl)azetidine-3-carboxylic acid TFA (1307810-22-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: methanol / acetic acid / 1,2-dichloro-ethane / 1 h / 80 °C

1.2: 1 h / 20 °C

2.1: water; methanol

With methanol; acetic acid; In methanol; water; 1,2-dichloro-ethane;

upstream raw materials:

1-((2-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho[2,1-d]thiazol-7-yl)methyl)azetidine-3-carboxylic acid, TFA salt

trifluoroacetic acid

5-(7-methoxy-4,5-dihydronaphtho[2,1-d]thiazol-2-yl)-3-phenyl-4-(trifluoromethyl)isoxazole

2-(3-phenyl-4-(tr ifluoromethyl ) isoxazol-5-yl)-4,5-dihydronaphtho[2,1-d]thiazol-7-ol