(R)-2-(((9H-fluoren-9-yl)-methoxy)carbonylamino)-2-(3,5-dichloro-4-hydroxyphenyl)acetic acid

Base Information

Chemical Name:(R)-2-(((9H-fluoren-9-yl)-methoxy)carbonylamino)-2-(3,5-dichloro-4-hydroxyphenyl)acetic acid
CAS No.:1027761-55-2
Molecular Formula:C₂₃H₁₇Cl₂NO₅
Molecular Weight:458.298
Hs Code.:

Synonyms:(R)-2-(((9H-fluoren-9-yl)-methoxy)carbonylamino)-2-(3,5-dichloro-4-hydroxyphenyl)acetic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-(((9H-fluoren-9-yl)-methoxy)carbonylamino)-2-(3,5-dichloro-4-hydroxyphenyl)acetic acid

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Technology Process of (R)-2-(((9H-fluoren-9-yl)-methoxy)carbonylamino)-2-(3,5-dichloro-4-hydroxyphenyl)acetic acid

There total 1 articles about (R)-2-(((9H-fluoren-9-yl)-methoxy)carbonylamino)-2-(3,5-dichloro-4-hydroxyphenyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 28920-43-6
(fluorenylmethoxy)carbonyl chloride

: 25698-18-4
(R)-2-amino-2-(3,5-dichloro-4-hydroxyphenyl)acetic acid

: 1027761-55-2
(R)-2-(((9H-fluoren-9-yl)-methoxy)carbonylamino)-2-(3,5-dichloro-4-hydroxyphenyl)acetic acid

Guidance literature:: With sodium hydrogencarbonate; In 1,4-dioxane; water; for 12h;
DOI:10.1021/ja907193b

Reference yield: 98.0%

: C₂₅H₂₇BrN₂O₄

: 1027761-55-2
(R)-2-(((9H-fluoren-9-yl)-methoxy)carbonylamino)-2-(3,5-dichloro-4-hydroxyphenyl)acetic acid

: 1195785-25-1
(9H-fluoren-9-yl)methyl (R)-2-((R)-1-(3'-acetamido-4'-bromo-5,6-dimethoxybiphenyl-3-yl)-2-(benzyloxy)ethylamino)-1-(3,5-dichloro-4-hydroxyphenyl)-2-oxoethylcarbamate

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; water; N,N-dimethyl-formamide; at -20 ℃; for 16h; optical yield given as %de; diastereoselective reaction;
DOI:10.1021/ja907193b

Reference yield: 96.0%

: 1027761-55-2
(R)-2-(((9H-fluoren-9-yl)-methoxy)carbonylamino)-2-(3,5-dichloro-4-hydroxyphenyl)acetic acid

: 1229117-58-1
C₄₈H₄₆BrCl₂N₅O₁₂

: 1229117-59-2
C₆₆H₅₃BrCl₄N₆O₁₄

Guidance literature:: C₄₈H₄₆BrCl₂N₅O₁₂; With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 1h; Inert atmosphere;

(R)-2-(((9H-fluoren-9-yl)-methoxy)carbonylamino)-2-(3,5-dichloro-4-hydroxyphenyl)acetic acid; With 2,6-dimethylpyridine; HATU; In tetrahydrofuran; dichloromethane; at 0 ℃; for 3h; Inert atmosphere;
DOI:10.1021/ja102304p