Methyl-2-deoxy-beta-D-ribofuranoside

Base Information

• Chemical Name: Methyl-2-deoxy-beta-D-ribofuranoside
• CAS No.: 51255-18-6
• Molecular Formula: C6H12O4
• Molecular Weight: 148.16
• Hs Code.: 2932190090
• Mol file: 51255-18-6.mol

Synonyms:Methyl2-deoxy-b-D-erythro-pentofuranoside;Methyl 2-deoxy-b-D-ribofuranoside;Methyl b-D-2-deoxyribofuranoside;NSC 68139;

Chemical Property of Methyl-2-deoxy-beta-D-ribofuranoside

Chemical Property:

• Vapor Pressure: 0.000169mmHg at 25°C
• Refractive Index: 1.487
• Boiling Point: 294.5 °C at 760 mmHg
• PKA: 13.81±0.60(Predicted)
• Flash Point: 131.9 °C
• PSA: 58.92000
• Density: 1.24 g/cm³
• LogP: -0.89900

Purity/Quality:

99% ^*data from raw suppliers

Methyl 2-deoxy-b-D-ribofuranoside ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl-2-deoxy-beta-D-ribofuranoside

There total 35 articles about Methyl-2-deoxy-beta-D-ribofuranoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + D-2-deoxyribose (452-51-7,13046-70-3,29780-54-9,36792-87-7,36792-88-8,113890-35-0,113890-38-3) → 1-O-methyl-2-deoxy-D-ribofuranoside (51255-17-5,51255-18-6,60134-26-1,89577-26-4,96038-80-1,96039-31-5,144301-84-8,144301-85-9)

Guidance literature:

sulfuric acid; Ambient temperature;

DOI:10.1016/S0040-4039(00)96753-4

Reference yield: 100.0%

D-2-deoxyribose (452-51-7,13046-70-3,29780-54-9,36792-87-7,36792-88-8,113890-35-0,113890-38-3) + acetyl chloride (75-36-5) → 1-O-methyl-2-deoxy-D-ribofuranoside (51255-17-5,51255-18-6,60134-26-1,89577-26-4,96038-80-1,96039-31-5,144301-84-8,144301-85-9)

Guidance literature:

In methanol; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1016/j.tet.2013.08.038

Reference yield: 100.0%

methanol (67-56-1) + 2-Deoxy-D-ribose (533-67-5) → 1-O-methyl-2-deoxy-D-ribofuranoside (51255-17-5,51255-18-6,60134-26-1,89577-26-4,96038-80-1,96039-31-5,144301-84-8,144301-85-9)

Guidance literature:

With hydrogenchloride;

DOI:10.1021/ja8043695

upstream raw materials:

2-Deoxy-D-ribose

methanol

2-deoxy-D-ribose

(2R,3S)-2-(hydroxymethyl)tetrahydrofuran-3-ol

Downstream raw materials:

methyl 3,5-dibenzoyloxy-2-deoxy-β-D-erythropentofuranoside

methyl 3,5-dibenzoyloxy-2-deoxy-α-D-erythropentofuranoside

methyl 2-deoxy-5-O-trityl-α-D-erythro-pentofuranoside

methyl 2-deoxy-5-O-trityl-β-D-erythro-pentofuranoside

Refernces

• 1、 -. "2-deoxy-D-ribose derivative". Paragraph 0048-0050; 0055-0057. . Retrieved 2020/08/09.
• 2、 Shiozaki, Yoko,Sakurai, Shunya,Sakamoto, Ryu,Matsumoto, Akira,Maruoka, Keiji. "Iron-Catalyzed Radical Cleavage/C?C Bond Formation of Acetal-Derived Alkylsilyl Peroxides". supporting information. p. 573 - 576. Retrieved 2020/02/20.