Technology Process of 3,4,5,6-tetrahydro-2-(4-methoxyphenyl)-2H-thiopyran
There total 5 articles about 3,4,5,6-tetrahydro-2-(4-methoxyphenyl)-2H-thiopyran which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
sulfure de pentamethylene;
With
N-chloro-succinimide;
In
benzene;
at 20 - 30 ℃;
for 1.5h;
4-methoxyphenyl magnesium bromide;
In
diethyl ether;
at 10 - 20 ℃;
for 17h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: aluminum (III) chloride / dichloromethane / 2 h / 0 - 20 °C
2.1: sodium tetrahydroborate / methanol / 1 h / 0 - 20 °C
3.1: potassium ethyl xanthogenate / acetone / 12 h / 0 - 20 °C
3.2: 12 h / 0 - 20 °C
4.1: sodium hydride / tetrahydrofuran
With
aluminum (III) chloride; sodium tetrahydroborate; potassium ethyl xanthogenate; sodium hydride;
In
tetrahydrofuran; methanol; dichloromethane; acetone;
1.1: |Friedel-Crafts Acylation;
DOI:10.5012/bkcs.2013.34.8.2317
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: aluminum (III) chloride / dichloromethane / 2 h / 0 - 20 °C
2.1: sodium tetrahydroborate / methanol / 1 h / 0 - 20 °C
3.1: potassium ethyl xanthogenate / acetone / 12 h / 0 - 20 °C
3.2: 12 h / 0 - 20 °C
4.1: sodium hydride / tetrahydrofuran
With
aluminum (III) chloride; sodium tetrahydroborate; potassium ethyl xanthogenate; sodium hydride;
In
tetrahydrofuran; methanol; dichloromethane; acetone;
1.1: |Friedel-Crafts Acylation;
DOI:10.5012/bkcs.2013.34.8.2317
