(4R,5S)-3-[(2E)-2-butenoyl]-1,5-dimethyl-4-phenyl-2-imidazolidinone

Base Information

• Chemical Name: (4R,5S)-3-[(2E)-2-butenoyl]-1,5-dimethyl-4-phenyl-2-imidazolidinone
• CAS No.: 128947-01-3
• Molecular Formula: C₁₅H₁₈N₂O₂
• Molecular Weight: 258.32
• Mol file: 128947-01-3.mol

Synonyms:(4R,5S)-3-[(2E)-2-butenoyl]-1,5-dimethyl-4-phenyl-2-imidazolidinone

Chemical Property of (4R,5S)-3-[(2E)-2-butenoyl]-1,5-dimethyl-4-phenyl-2-imidazolidinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4R,5S)-3-[(2E)-2-butenoyl]-1,5-dimethyl-4-phenyl-2-imidazolidinone

There total 3 articles about (4R,5S)-3-[(2E)-2-butenoyl]-1,5-dimethyl-4-phenyl-2-imidazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

trans-chrotonyl chloride (625-35-4,3488-22-0,10487-71-5) + (4R,5S)-1,5-dimethyl-4-phenylimidazolidin-2-one (92841-65-1) → (4R,5S)-3-[(2E)-2-butenoyl]-1,5-dimethyl-4-phenyl-2-imidazolidinone (128947-01-3)

Guidance literature:

With 2,3-Dimethylaniline;

DOI:10.1016/S0957-4166(00)86059-0

Reference yield:

(+)-(1S,2R)-ephedrine hydrochloride (24221-86-1) → (4R,5S)-3-[(2E)-2-butenoyl]-1,5-dimethyl-4-phenyl-2-imidazolidinone (128947-01-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 50 percent / a) 180 deg C, 30 min, b) 200 deg C, 1 h

2: 75 percent / dimethylaniline / CH₂Cl₂ / Heating

With 2,3-Dimethylaniline; In dichloromethane;

DOI:10.1016/S0040-4020(01)88188-6

Reference yield:

(4R,5S)-1,5-dimethyl-4-phenylimidazolidin-2-one (92841-65-1) + crotonyl chloride (10487-71-5) → (4R,5S)-3-[(2E)-2-butenoyl]-1,5-dimethyl-4-phenyl-2-imidazolidinone (128947-01-3)

Guidance literature:

With methylmagnesium bromide; Yield given. Multistep reaction; 1.) THF, 0 deg C, 30 min, 2.) THF, 3 h;

DOI:10.1016/0957-4166(96)00163-2

upstream raw materials:

trans-chrotonyl chloride

(4R,5S)-1,5-dimethyl-4-phenylimidazolidin-2-one

crotonyl chloride

(+)-(1S,2R)-ephedrine hydrochloride

Downstream raw materials:

(4R,5S)-1,5-Dimethyl-4-phenyl-3-((R)-3,4,4-trimethyl-hex-5-enoyl)-imidazolidin-2-one

(4R,5S)-1,5-Dimethyl-4-phenyl-3-((S)-3,4,4-trimethyl-hex-5-enoyl)-imidazolidin-2-one

(4R,5S)-1,5-Dimethyl-3-((R)-3-methyl-hex-5-enoyl)-4-phenyl-imidazolidin-2-one

(4R,5S)-1,5-Dimethyl-4-phenyl-3-((S)-3-phenyl-butyryl)-imidazolidin-2-one