(4-(((4-(2-(((R,E)-4-((R)-1-(7-ethoxy-7-oxoheptyl)-5-oxopyrrolidin-2-yl)-1,1-difluoro-1-phenylbut-3-en-2-yl)oxy)-2-oxoethyl)phenoxy)carbonyl)amino)-1-hydroxybutane-1,1-diyl)diphosphonic acid

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Chemical Name:(4-(((4-(2-(((R,E)-4-((R)-1-(7-ethoxy-7-oxoheptyl)-5-oxopyrrolidin-2-yl)-1,1-difluoro-1-phenylbut-3-en-2-yl)oxy)-2-oxoethyl)phenoxy)carbonyl)amino)-1-hydroxybutane-1,1-diyl)diphosphonic acid
CAS No.:1350837-01-2
Molecular Formula:C₃₆H₄₈F₂N₂O₁₄P₂
Molecular Weight:832.726
Hs Code.:

(4-(((4-(2-(((R,E)-4-((R)-1-(7-ethoxy-7-oxoheptyl)-5-oxopyrrolidin-2-yl)-1,1-difluoro-1-phenylbut-3-en-2-yl)oxy)-2-oxoethyl)phenoxy)carbonyl)amino)-1-hydroxybutane-1,1-diyl)diphosphonic acid

Synonyms:(4-(((4-(2-(((R,E)-4-((R)-1-(7-ethoxy-7-oxoheptyl)-5-oxopyrrolidin-2-yl)-1,1-difluoro-1-phenylbut-3-en-2-yl)oxy)-2-oxoethyl)phenoxy)carbonyl)amino)-1-hydroxybutane-1,1-diyl)diphosphonic acid

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Chemical Property of (4-(((4-(2-(((R,E)-4-((R)-1-(7-ethoxy-7-oxoheptyl)-5-oxopyrrolidin-2-yl)-1,1-difluoro-1-phenylbut-3-en-2-yl)oxy)-2-oxoethyl)phenoxy)carbonyl)amino)-1-hydroxybutane-1,1-diyl)diphosphonic acid

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Technology Process of (4-(((4-(2-(((R,E)-4-((R)-1-(7-ethoxy-7-oxoheptyl)-5-oxopyrrolidin-2-yl)-1,1-difluoro-1-phenylbut-3-en-2-yl)oxy)-2-oxoethyl)phenoxy)carbonyl)amino)-1-hydroxybutane-1,1-diyl)diphosphonic acid

There total 7 articles about (4-(((4-(2-(((R,E)-4-((R)-1-(7-ethoxy-7-oxoheptyl)-5-oxopyrrolidin-2-yl)-1,1-difluoro-1-phenylbut-3-en-2-yl)oxy)-2-oxoethyl)phenoxy)carbonyl)amino)-1-hydroxybutane-1,1-diyl)diphosphonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1350837-00-1
ethyl 7-((R)-2-((R,E)-4,4-difluoro-3-(2-(4-((4-nitrophenoxy)carbonyloxy)phenyl)acetoxy)-4-phenylbut-1-enyl)-5-oxopyrrolidin-1-yl)heptanoate

: 66376-36-1
4-amino-1-hydroxybutylidenebisphosphonic acid

: 1350837-01-2
(4-(((4-(2-(((R,E)-4-((R)-1-(7-ethoxy-7-oxoheptyl)-5-oxopyrrolidin-2-yl)-1,1-difluoro-1-phenylbut-3-en-2-yl)oxy)-2-oxoethyl)phenoxy)carbonyl)amino)-1-hydroxybutane-1,1-diyl)diphosphonic acid

Guidance literature:: With triethylamine; In 1,4-dioxane; water; at 20 ℃; for 1h;
DOI:10.1016/j.bmc.2012.01.024

Reference yield:

: 1365735-34-7
(R,E)-4-((R)-1-(7-ethoxy-7-oxoheptyl)-5-oxopyrrolidin-2-yl)-1,1-difluoro-1-phenylbut-3-en-2-yl 2-acetoxybenzoate

: 1350837-01-2
(4-(((4-(2-(((R,E)-4-((R)-1-(7-ethoxy-7-oxoheptyl)-5-oxopyrrolidin-2-yl)-1,1-difluoro-1-phenylbut-3-en-2-yl)oxy)-2-oxoethyl)phenoxy)carbonyl)amino)-1-hydroxybutane-1,1-diyl)diphosphonic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogenchloride / ethanol / 3.67 h / 0 - 20 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 5 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 20 °C

4.1: sodium hydride / tetrahydrofuran; mineral oil / 0.08 h

4.2: 18 h / 20 °C

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

6.1: triethylamine / dichloromethane / 2 h / 20 °C

7.1: triethylamine / 1,4-dioxane; water / 1 h / 20 °C

With hydrogenchloride; tetrabutyl ammonium fluoride; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmc.2012.01.024

Reference yield:

: 1350836-97-3
perfluorophenyl 2-(4-(tert-butyldimethylsilyloxy)-phenyl)acetate

: 1350837-01-2
(4-(((4-(2-(((R,E)-4-((R)-1-(7-ethoxy-7-oxoheptyl)-5-oxopyrrolidin-2-yl)-1,1-difluoro-1-phenylbut-3-en-2-yl)oxy)-2-oxoethyl)phenoxy)carbonyl)amino)-1-hydroxybutane-1,1-diyl)diphosphonic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.08 h

1.2: 18 h / 20 °C

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

3.1: triethylamine / dichloromethane / 2 h / 20 °C

4.1: triethylamine / 1,4-dioxane; water / 1 h / 20 °C

With tetrabutyl ammonium fluoride; sodium hydride; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; mineral oil;
DOI:10.1016/j.bmc.2012.01.024