(R,E)-4-((R)-1-(7-ethoxy-7-oxoheptyl)-5-oxopyrrolidin-2-yl)-1,1-difluoro-1-phenylbut-3-en-2-yl 2-acetoxybenzoate

Base Information

Chemical Name:(R,E)-4-((R)-1-(7-ethoxy-7-oxoheptyl)-5-oxopyrrolidin-2-yl)-1,1-difluoro-1-phenylbut-3-en-2-yl 2-acetoxybenzoate
CAS No.:1365735-34-7
Molecular Formula:C₃₂H₃₇F₂NO₇
Molecular Weight:585.645
Hs Code.:

Synonyms:(R,E)-4-((R)-1-(7-ethoxy-7-oxoheptyl)-5-oxopyrrolidin-2-yl)-1,1-difluoro-1-phenylbut-3-en-2-yl 2-acetoxybenzoate

Suppliers and Price of (R,E)-4-((R)-1-(7-ethoxy-7-oxoheptyl)-5-oxopyrrolidin-2-yl)-1,1-difluoro-1-phenylbut-3-en-2-yl 2-acetoxybenzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R,E)-4-((R)-1-(7-ethoxy-7-oxoheptyl)-5-oxopyrrolidin-2-yl)-1,1-difluoro-1-phenylbut-3-en-2-yl 2-acetoxybenzoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R,E)-4-((R)-1-(7-ethoxy-7-oxoheptyl)-5-oxopyrrolidin-2-yl)-1,1-difluoro-1-phenylbut-3-en-2-yl 2-acetoxybenzoate

There total 1 articles about (R,E)-4-((R)-1-(7-ethoxy-7-oxoheptyl)-5-oxopyrrolidin-2-yl)-1,1-difluoro-1-phenylbut-3-en-2-yl 2-acetoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1350836-65-5
ethyl 7-((R)-2-((R,E)-4,4-difluoro-3-hydroxy-4-phenylbut-1-en-1-yl)-5-oxopyrrolidin-1-yl)heptanoate

: 5538-51-2
O-acetylsalicyloyl chloride

: 1365735-34-7
(R,E)-4-((R)-1-(7-ethoxy-7-oxoheptyl)-5-oxopyrrolidin-2-yl)-1,1-difluoro-1-phenylbut-3-en-2-yl 2-acetoxybenzoate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 18h;
DOI:10.1016/j.bmc.2012.01.024

Reference yield:

: 1365735-34-7
(R,E)-4-((R)-1-(7-ethoxy-7-oxoheptyl)-5-oxopyrrolidin-2-yl)-1,1-difluoro-1-phenylbut-3-en-2-yl 2-acetoxybenzoate

: 1350836-99-5
ethyl 7-((R)-2-((R,E)-4,4-difluoro-3-(2-(4-hydroxyphenyl)acetoxy)-4-phenylbut-1-enyl)-5-oxopyrrolidin-1-yl)heptanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride / ethanol / 3.67 h / 0 - 20 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 5 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 20 °C

4.1: sodium hydride / tetrahydrofuran; mineral oil / 0.08 h

4.2: 18 h / 20 °C

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

With hydrogenchloride; tetrabutyl ammonium fluoride; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmc.2012.01.024

Reference yield:

: 1365735-34-7
(R,E)-4-((R)-1-(7-ethoxy-7-oxoheptyl)-5-oxopyrrolidin-2-yl)-1,1-difluoro-1-phenylbut-3-en-2-yl 2-acetoxybenzoate

: 1350837-00-1
ethyl 7-((R)-2-((R,E)-4,4-difluoro-3-(2-(4-((4-nitrophenoxy)carbonyloxy)phenyl)acetoxy)-4-phenylbut-1-enyl)-5-oxopyrrolidin-1-yl)heptanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride / ethanol / 3.67 h / 0 - 20 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 5 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 20 °C

4.1: sodium hydride / tetrahydrofuran; mineral oil / 0.08 h

4.2: 18 h / 20 °C

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

6.1: triethylamine / dichloromethane / 2 h / 20 °C

With hydrogenchloride; tetrabutyl ammonium fluoride; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmc.2012.01.024