ethyl 7-((R)-2-((R,E)-3-(2-(4-(tert-butyldimethylsilyloxy)-phenyl)acetoxy)-4,4-difluoro-4-phenylbut-1-enyl)-5-oxopyrrolidin-1-yl)heptanoate

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Chemical Name:ethyl 7-((R)-2-((R,E)-3-(2-(4-(tert-butyldimethylsilyloxy)-phenyl)acetoxy)-4,4-difluoro-4-phenylbut-1-enyl)-5-oxopyrrolidin-1-yl)heptanoate
CAS No.:1350836-98-4
Molecular Formula:C₃₇H₅₁F₂NO₆Si
Molecular Weight:671.897
Hs Code.:

Synonyms:ethyl 7-((R)-2-((R,E)-3-(2-(4-(tert-butyldimethylsilyloxy)-phenyl)acetoxy)-4,4-difluoro-4-phenylbut-1-enyl)-5-oxopyrrolidin-1-yl)heptanoate

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Chemical Property of ethyl 7-((R)-2-((R,E)-3-(2-(4-(tert-butyldimethylsilyloxy)-phenyl)acetoxy)-4,4-difluoro-4-phenylbut-1-enyl)-5-oxopyrrolidin-1-yl)heptanoate

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Technology Process of ethyl 7-((R)-2-((R,E)-3-(2-(4-(tert-butyldimethylsilyloxy)-phenyl)acetoxy)-4,4-difluoro-4-phenylbut-1-enyl)-5-oxopyrrolidin-1-yl)heptanoate

There total 4 articles about ethyl 7-((R)-2-((R,E)-3-(2-(4-(tert-butyldimethylsilyloxy)-phenyl)acetoxy)-4,4-difluoro-4-phenylbut-1-enyl)-5-oxopyrrolidin-1-yl)heptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1350836-97-3
perfluorophenyl 2-(4-(tert-butyldimethylsilyloxy)-phenyl)acetate

: 1350836-65-5
ethyl 7-((R)-2-((R,E)-4,4-difluoro-3-hydroxy-4-phenylbut-1-en-1-yl)-5-oxopyrrolidin-1-yl)heptanoate

: 1350836-98-4
ethyl 7-((R)-2-((R,E)-3-(2-(4-(tert-butyldimethylsilyloxy)-phenyl)acetoxy)-4,4-difluoro-4-phenylbut-1-enyl)-5-oxopyrrolidin-1-yl)heptanoate

Guidance literature:: ethyl 7-((R)-2-((R,E)-4,4-difluoro-3-hydroxy-4-phenylbut-1-en-1-yl)-5-oxopyrrolidin-1-yl)heptanoate; With sodium hydride; In tetrahydrofuran; mineral oil; for 0.0833333h;

perfluorophenyl 2-(4-(tert-butyldimethylsilyloxy)-phenyl)acetate; In tetrahydrofuran; mineral oil; at 20 ℃; for 18h;
DOI:10.1016/j.bmc.2012.01.024

Reference yield:

: 1381926-83-5
(R,E)-4-((R)-1-(7-ethoxy-7-oxoheptyl)-5-oxopyrrolidin-2-yl)-1,1-difluoro-1-phenylbut-3-en-2-yl 2-hydroxybenzoate

: 1350836-98-4
ethyl 7-((R)-2-((R,E)-3-(2-(4-(tert-butyldimethylsilyloxy)-phenyl)acetoxy)-4,4-difluoro-4-phenylbut-1-enyl)-5-oxopyrrolidin-1-yl)heptanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 5 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 20 °C

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.08 h

3.2: 18 h / 20 °C

With sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmc.2012.01.024

Reference yield:

: 1365735-34-7
(R,E)-4-((R)-1-(7-ethoxy-7-oxoheptyl)-5-oxopyrrolidin-2-yl)-1,1-difluoro-1-phenylbut-3-en-2-yl 2-acetoxybenzoate

: 1350836-98-4
ethyl 7-((R)-2-((R,E)-3-(2-(4-(tert-butyldimethylsilyloxy)-phenyl)acetoxy)-4,4-difluoro-4-phenylbut-1-enyl)-5-oxopyrrolidin-1-yl)heptanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / ethanol / 3.67 h / 0 - 20 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 5 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 20 °C

4.1: sodium hydride / tetrahydrofuran; mineral oil / 0.08 h

4.2: 18 h / 20 °C

With hydrogenchloride; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmc.2012.01.024