ethyl 7-((R)-2-((R,E)-4,4-difluoro-3-(2-(4-hydroxyphenyl)acetoxy)-4-phenylbut-1-enyl)-5-oxopyrrolidin-1-yl)heptanoate

Base Information

• Chemical Name: ethyl 7-((R)-2-((R,E)-4,4-difluoro-3-(2-(4-hydroxyphenyl)acetoxy)-4-phenylbut-1-enyl)-5-oxopyrrolidin-1-yl)heptanoate
• CAS No.: 1350836-99-5
• Molecular Formula: C₃₁H₃₇F₂NO₆
• Molecular Weight: 557.635

Synonyms:ethyl 7-((R)-2-((R,E)-4,4-difluoro-3-(2-(4-hydroxyphenyl)acetoxy)-4-phenylbut-1-enyl)-5-oxopyrrolidin-1-yl)heptanoate

Chemical Property of ethyl 7-((R)-2-((R,E)-4,4-difluoro-3-(2-(4-hydroxyphenyl)acetoxy)-4-phenylbut-1-enyl)-5-oxopyrrolidin-1-yl)heptanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of ethyl 7-((R)-2-((R,E)-4,4-difluoro-3-(2-(4-hydroxyphenyl)acetoxy)-4-phenylbut-1-enyl)-5-oxopyrrolidin-1-yl)heptanoate

There total 5 articles about ethyl 7-((R)-2-((R,E)-4,4-difluoro-3-(2-(4-hydroxyphenyl)acetoxy)-4-phenylbut-1-enyl)-5-oxopyrrolidin-1-yl)heptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R,E)-4-((R)-1-(7-ethoxy-7-oxoheptyl)-5-oxopyrrolidin-2-yl)-1,1-difluoro-1-phenylbut-3-en-2-yl 2-acetoxybenzoate (1365735-34-7) → ethyl 7-((R)-2-((R,E)-4,4-difluoro-3-(2-(4-hydroxyphenyl)acetoxy)-4-phenylbut-1-enyl)-5-oxopyrrolidin-1-yl)heptanoate (1350836-99-5)

Guidance literature:

Multi-step reaction with 5 steps

1.1: hydrogenchloride / ethanol / 3.67 h / 0 - 20 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 5 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 20 °C

4.1: sodium hydride / tetrahydrofuran; mineral oil / 0.08 h

4.2: 18 h / 20 °C

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

With hydrogenchloride; tetrabutyl ammonium fluoride; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;

DOI:10.1016/j.bmc.2012.01.024

Reference yield:

(R,E)-4-((R)-1-(7-ethoxy-7-oxoheptyl)-5-oxopyrrolidin-2-yl)-1,1-difluoro-1-phenylbut-3-en-2-yl 2-hydroxybenzoate (1381926-83-5) → ethyl 7-((R)-2-((R,E)-4,4-difluoro-3-(2-(4-hydroxyphenyl)acetoxy)-4-phenylbut-1-enyl)-5-oxopyrrolidin-1-yl)heptanoate (1350836-99-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 5 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 20 °C

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.08 h

3.2: 18 h / 20 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

With tetrabutyl ammonium fluoride; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;

DOI:10.1016/j.bmc.2012.01.024

Reference yield:

perfluorophenyl 2-(4-(tert-butyldimethylsilyloxy)-phenyl)acetate (1350836-97-3) → ethyl 7-((R)-2-((R,E)-4,4-difluoro-3-(2-(4-hydroxyphenyl)acetoxy)-4-phenylbut-1-enyl)-5-oxopyrrolidin-1-yl)heptanoate (1350836-99-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.08 h

1.2: 18 h / 20 °C

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

With tetrabutyl ammonium fluoride; sodium hydride; In tetrahydrofuran; mineral oil;

DOI:10.1016/j.bmc.2012.01.024

upstream raw materials:

(R,E)-4-((R)-1-(7-ethoxy-7-oxoheptyl)-5-oxopyrrolidin-2-yl)-1,1-difluoro-1-phenylbut-3-en-2-yl 2-hydroxybenzoate

perfluorophenyl 2-(4-(tert-butyldimethylsilyloxy)-phenyl)acetate

ethyl 7-((R)-2-((R,E)-4,4-difluoro-3-hydroxy-4-phenylbut-1-en-1-yl)-5-oxopyrrolidin-1-yl)heptanoate

(R,E)-4-((R)-1-(7-ethoxy-7-oxoheptyl)-5-oxopyrrolidin-2-yl)-1,1-difluoro-1-phenylbut-3-en-2-yl 2-acetoxybenzoate

Downstream raw materials:

(4-(((4-(2-(((R,E)-4-((R)-1-(7-ethoxy-7-oxoheptyl)-5-oxopyrrolidin-2-yl)-1,1-difluoro-1-phenylbut-3-en-2-yl)oxy)-2-oxoethyl)phenoxy)carbonyl)amino)-1-hydroxybutane-1,1-diyl)diphosphonic acid

ethyl 7-((R)-2-((R,E)-4,4-difluoro-3-(2-(4-((4-nitrophenoxy)carbonyloxy)phenyl)acetoxy)-4-phenylbut-1-enyl)-5-oxopyrrolidin-1-yl)heptanoate

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