phenyl (4-(4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamido)-2-fluorophenoxy)pyridin-2-yl)carbamate

Base Information

Chemical Name:phenyl (4-(4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamido)-2-fluorophenoxy)pyridin-2-yl)carbamate
CAS No.:1558030-54-8
Molecular Formula:C₃₀H₂₄FN₅O₅
Molecular Weight:553.549
Hs Code.:

Synonyms:phenyl (4-(4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamido)-2-fluorophenoxy)pyridin-2-yl)carbamate

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Chemical Property of phenyl (4-(4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamido)-2-fluorophenoxy)pyridin-2-yl)carbamate

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Technology Process of phenyl (4-(4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamido)-2-fluorophenoxy)pyridin-2-yl)carbamate

There total 8 articles about phenyl (4-(4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamido)-2-fluorophenoxy)pyridin-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1552280-62-2
N-(4-((2-aminopyridin-4-yl)oxy)-3-fluorophenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide

: 1885-14-9
phenyl chloroformate

: 1558030-54-8
phenyl (4-(4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamido)-2-fluorophenoxy)pyridin-2-yl)carbamate

Guidance literature:: With pyridine; In dichloromethane; at 0 - 20 ℃; for 2.5h;

Reference yield:

: 99586-65-9
4-chloropicolinamide

: 1558030-54-8
phenyl (4-(4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamido)-2-fluorophenoxy)pyridin-2-yl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / dimethyl sulfoxide; mineral oil / 20 h / 160 °C

2: [bis(acetoxy)iodo]benzene / water; ethyl acetate; acetonitrile / 8.5 h / 0 - 20 °C

3: pyridine / dichloromethane / 2.5 h / 0 - 20 °C

With pyridine; [bis(acetoxy)iodo]benzene; sodium hydride; In dichloromethane; water; dimethyl sulfoxide; ethyl acetate; acetonitrile; mineral oil;

Reference yield:

: 399-96-2
4-amino-2-fluorophenol

: 1558030-54-8
phenyl (4-(4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamido)-2-fluorophenoxy)pyridin-2-yl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 45 °C

2: sodium hydride / dimethyl sulfoxide; mineral oil / 20 h / 160 °C

3: [bis(acetoxy)iodo]benzene / water; ethyl acetate; acetonitrile / 8.5 h / 0 - 20 °C

4: pyridine / dichloromethane / 2.5 h / 0 - 20 °C

With pyridine; 1-hydroxy-7-aza-benzotriazole; [bis(acetoxy)iodo]benzene; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; water; dimethyl sulfoxide; ethyl acetate; acetonitrile; mineral oil;