9H-fluoren-9-ylmethyl N-[(1S)-1-benzyl-2-benzotriazol-1-yl-2-oxoethyl]carbamate

Base Information

• Chemical Name: 9H-fluoren-9-ylmethyl N-[(1S)-1-benzyl-2-benzotriazol-1-yl-2-oxoethyl]carbamate
• CAS No.: 860800-19-7
• Molecular Formula: C₃₀H₂₄N₄O₃
• Molecular Weight: 488.546

Synonyms:9H-fluoren-9-ylmethyl N-[(1S)-1-benzyl-2-benzotriazol-1-yl-2-oxoethyl]carbamate

Chemical Property of 9H-fluoren-9-ylmethyl N-[(1S)-1-benzyl-2-benzotriazol-1-yl-2-oxoethyl]carbamate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

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Technology Process of 9H-fluoren-9-ylmethyl N-[(1S)-1-benzyl-2-benzotriazol-1-yl-2-oxoethyl]carbamate

There total 2 articles about 9H-fluoren-9-ylmethyl N-[(1S)-1-benzyl-2-benzotriazol-1-yl-2-oxoethyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1,2,3-Benzotriazole (95-14-7,27556-51-0) + N-Fmoc L-Phe (35661-40-6) → 9H-fluoren-9-ylmethyl N-[(1S)-1-benzyl-2-benzotriazol-1-yl-2-oxoethyl]carbamate (860800-19-7)

Guidance literature:

With pyridine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

DOI:10.1016/j.tetlet.2018.12.046

Reference yield:

1,2,3-Benzotriazole (95-14-7,27556-51-0) + 2S-flouren-9-ylmethoxycarbonylamino-3-phenylpropionyl chloride (103321-57-9) → 9H-fluoren-9-ylmethyl N-[(1S)-1-benzyl-2-benzotriazol-1-yl-2-oxoethyl]carbamate (860800-19-7)

Guidance literature:

In tetrahydrofuran; at 20 ℃;

DOI:10.1021/jo8026214

Reference yield: 100.0%

9H-fluoren-9-ylmethyl N-[(1S)-1-benzyl-2-benzotriazol-1-yl-2-oxoethyl]carbamate (860800-19-7) + (2-aminophenyl)(phenyl)methanone (2835-77-0) → C37H30N2O4

Guidance literature:

With trifluoroacetic acid; In toluene; for 3h; Solvent;

DOI:10.1002/ejoc.201801567

upstream raw materials:

1,2,3-Benzotriazole

N-Fmoc L-Phe

2S-flouren-9-ylmethoxycarbonylamino-3-phenylpropionyl chloride

Downstream raw materials:

H-L-Trp-L-Lys(Nε-Cc)-L-Met-L-Phe-NH2

H-L-Pro-L-Phe-L-Lys(Nε-Cc)-NH2

Fmoc-Phe-Ala-OH

Z-L-Thr-L-Cys(S-Fmoc-L-Phe)-OH

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