Technology Process of L-Alanine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-phenylalanyl-
There total 13 articles about L-Alanine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-phenylalanyl- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
N-Fmoc L-Phe;
With
N-ethyl-N,N-diisopropylamine; 16-methylheptadecanoic acid chloride;
In
toluene; acetonitrile;
at 0 ℃;
L-alanin;
With
N,O-bis-(trimethylsilyl)-acetamide;
In
toluene; acetonitrile;
at 0 ℃;
for 2h;
DOI:10.1021/acs.oprd.1c00078
- Guidance literature:
-
With
triethylamine;
In
water; acetonitrile;
at 20 ℃;
for 6h;
DOI:10.1039/b905730g
- Guidance literature:
-
tert-butyl L-alaninate hydrochloride;
With
NALdehyde-4 derivatised aminomethyl-polystyrene resin; sodium cyanoborohydride;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 16h;
N-Fmoc L-Phe;
With
1,3-di-tert-butylcarbodiimide;
In
dichloromethane; N,N-dimethyl-formamide;
at 20 ℃;
for 16h;
With
trifluoroacetic acid;
In
dichloromethane;
at 20 ℃;
for 2h;
DOI:10.1021/ol062410j
