6-Carboxyhexylphosphocholine p-Nitrophenyl Ester

Base Information

• Chemical Name: 6-Carboxyhexylphosphocholine p-Nitrophenyl Ester
• CAS No.: 73785-43-0
• Molecular Formula: C17H27 N2 O8 P
• Molecular Weight: 0
• Mol file: 73785-43-0.mol

Synonyms:2-[[Hydroxy[[6-(4-nitrophenoxy)-6-oxohexyl]oxy]phosphinyl]oxy]-N,N,N-trimethyl-ethanaminium Inner Sal;6-Carboxyhexylphosphocholine p-Nitrophenyl Ester;4-nitrophenyl-6-(O-phosphocholine)hydroxyhexanoate;2-[[Hydroxy[[6-(4-nitrophenoxy)-6-oxohexyl]oxy]phosphinyl]oxy]-N,N,N-trimethyl-ethanaminium Inner Salt

Chemical Property of 6-Carboxyhexylphosphocholine p-Nitrophenyl Ester

Chemical Property:

• PSA: 140.52000
• LogP: 3.04470
• Storage Temp.: Refrigerator
• Solubility.: Water

Purity/Quality:

98%Min ^*data from raw suppliers

6-Carboxyhexylphosphocholinep-NitrophenylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 6-Carboxyhexylphosphocholine p-Nitrophenyl Ester is a novel phosphorylcholine ester used in immmunological studies.

Technology Process of 6-Carboxyhexylphosphocholine p-Nitrophenyl Ester

There total 7 articles about 6-Carboxyhexylphosphocholine p-Nitrophenyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

6-(O-phosphorylcholine)hydroxyhexanoic acid (73839-24-4) + 1-nitro-4-trifluoroacetoxy-benzene (658-78-6) → p-nitrophenyl 6-(O-phosphorylcholine)hydroxyhexanoate (73785-43-0)

Guidance literature:

With 2,6-dimethylpyridine; In N,N-dimethyl-formamide; Ambient temperature;

DOI:10.1021/jo01303a029

Reference yield: 60.0%

4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + 6-(O-phosphorylcholine)hydroxyhexanoic acid (73839-24-4) → p-nitrophenyl 6-(O-phosphorylcholine)hydroxyhexanoate (73785-43-0) + C24H46N3O6P

Guidance literature:

With dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide;

DOI:10.1021/jo01303a029

Reference yield:

6-bromohexanoic acid (4224-70-8) → p-nitrophenyl 6-(O-phosphorylcholine)hydroxyhexanoate (73785-43-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 93 percent / H₂SO₄ / CH₂Cl₂ / Ambient temperature

2: 1) sodium formate, 2) KOH / 1) DMF, a) 110 deg C, 4h, b) RT, 2 days, 2) H₂O, 30-40 deg C, 4h

3: 1) triethylamine, 2) pyridine, H₂O / 1) RT, 1h, 2) RT

4: 34 percent / CHCl₃ / 8 h / Heating

5: DCC / dimethylformamide

With pyridine; potassium hydroxide; sulfuric acid; water; sodium formate; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; chloroform; N,N-dimethyl-formamide;

DOI:10.1021/jo01303a029

upstream raw materials:

4-nitro-phenol

6-(O-phosphorylcholine)hydroxyhexanoic acid

1-nitro-4-trifluoroacetoxy-benzene

6-bromohexanoic acid

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