1-(dibenzylamino)-N-methoxy-N-methylcyclopropanecarboxamide

Base Information

• Chemical Name: 1-(dibenzylamino)-N-methoxy-N-methylcyclopropanecarboxamide
• CAS No.: 1352303-16-2
• Molecular Formula: C₂₀H₂₄N₂O₂
• Molecular Weight: 324.423
• Mol file: 1352303-16-2.mol

Synonyms:1-(dibenzylamino)-N-methoxy-N-methylcyclopropanecarboxamide

Chemical Property of 1-(dibenzylamino)-N-methoxy-N-methylcyclopropanecarboxamide

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 1-(dibenzylamino)-N-methoxy-N-methylcyclopropanecarboxamide

There total 2 articles about 1-(dibenzylamino)-N-methoxy-N-methylcyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) + 1-(N,N-dibenzylamino)cyclopropanecarboxylic acid (119111-63-6) → 1-(dibenzylamino)-N-methoxy-N-methylcyclopropanecarboxamide (1352303-16-2)

Guidance literature:

1-(N,N-dibenzylamino)cyclopropanecarboxylic acid; With N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In acetonitrile; for 0.0833333h;

N,O-dimethylhydroxylamine*hydrochloride; With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 100 ℃; for 0.833333h; Microwave irradiation;

Reference yield:

benzyl bromide (100-39-0) → 1-(dibenzylamino)-N-methoxy-N-methylcyclopropanecarboxamide (1352303-16-2)

Guidance literature:

Multi-step reaction with 2 steps

1: tetraoctyl ammonium bromide; potassium carbonate; potassium hydroxide / acetonitrile / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine; HATU / acetonitrile / 0.92 h / 100 °C / Microwave irradiation

With tetraoctyl ammonium bromide; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; potassium hydroxide; In acetonitrile;

DOI:10.1021/ml2002136

Reference yield: 94.0%

1-(dibenzylamino)-N-methoxy-N-methylcyclopropanecarboxamide (1352303-16-2) + methyllithium (917-54-4) → 1-(1-(dibenzylamino)cyclopropyl)ethanone (1352303-17-3)

Guidance literature:

In tetrahydrofuran; for 1.5h;

upstream raw materials:

N,O-dimethylhydroxylamine*hydrochloride

1-(N,N-dibenzylamino)cyclopropanecarboxylic acid

benzyl bromide

Downstream raw materials:

1-(1-(dibenzylamino)cyclopropyl)ethanone