1-[4-(tert-butyl-diphenyl-silanyloxymethyl)-3-trimethylsilanyloxy-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

Base Information

Chemical Name:1-[4-(tert-butyl-diphenyl-silanyloxymethyl)-3-trimethylsilanyloxy-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione
CAS No.:448896-40-0
Molecular Formula:C₂₈H₃₈N₂O₅Si₂
Molecular Weight:538.791
Hs Code.:

1-[4-(<i>tert</i>-butyl-diphenyl-silanyloxymethyl)-3-trimethylsilanyloxy-tetrahydro-furan-2-yl]-1<i>H</i>-pyrimidine-2,4-dione

Synonyms:1-[4-(tert-butyl-diphenyl-silanyloxymethyl)-3-trimethylsilanyloxy-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

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Chemical Property of 1-[4-(tert-butyl-diphenyl-silanyloxymethyl)-3-trimethylsilanyloxy-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

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Technology Process of 1-[4-(tert-butyl-diphenyl-silanyloxymethyl)-3-trimethylsilanyloxy-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

There total 1 articles about 1-[4-(tert-butyl-diphenyl-silanyloxymethyl)-3-trimethylsilanyloxy-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 3442-82-8
1,3-bis(trimethylsilyl)uracil

: tert-Butyl-[(R)-1-(2,6-dioxa-bicyclo[3.1.0]hex-4-yl)methoxy]-diphenyl-silane

: 287933-76-0
1-((1R,2R,3R)-tetrahydro-2-hydroxy-3-(1,1-dimethylethyldiphenyl)-silyloxymethyl-1-furanyl)-2,4(1H,3H)-pyrimidinedione

: 448896-40-0
1-[4-(tert-butyl-diphenyl-silanyloxymethyl)-3-trimethylsilanyloxy-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

Guidance literature:: In chloroform-d1; at 20 ℃; for 36h;
DOI:10.1007/s007060200024

Reference yield: 100.0%

: 448896-40-0
1-[4-(tert-butyl-diphenyl-silanyloxymethyl)-3-trimethylsilanyloxy-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

: 287933-76-0
1-((1R,2R,3R)-tetrahydro-2-hydroxy-3-(1,1-dimethylethyldiphenyl)-silyloxymethyl-1-furanyl)-2,4(1H,3H)-pyrimidinedione

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; methanol; at 0 - 20 ℃; for 0.5h;
DOI:10.1007/s007060200024

Reference yield:

: 448896-40-0
1-[4-(tert-butyl-diphenyl-silanyloxymethyl)-3-trimethylsilanyloxy-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

: 448896-42-2
4-amino-1-((1R,2R,3R)-tetrahydro-2-(1,1-dimethylethyldiphenyl)-silyloxy-3-(1,1-dimethylethyldiphenyl)-silyloxymethyl-1-furanyl)-2(1H)-pyrimidinone

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / aq. HCl / methanol; tetrahydrofuran / 0.5 h / 0 - 20 °C

2: 81 percent / imidazole / dimethylformamide / 23 h / 20 °C

3: 93 percent / 4-chlorophenyl dichlorophosphate / pyridine / 28 h / 20 °C

4: 93 percent / sat. aq. NH₃ / dioxane / 72 h / 20 °C

With 1H-imidazole; hydrogenchloride; ammonium hydroxide; 4-chlorophenylphosphorodichloridate; In tetrahydrofuran; 1,4-dioxane; pyridine; methanol; N,N-dimethyl-formamide;
DOI:10.1007/s007060200024