2-(2,2-dimethylpropionylamino)-4,6-difluorobenzoic acid

Base Information

Chemical Name:2-(2,2-dimethylpropionylamino)-4,6-difluorobenzoic acid
CAS No.:1609122-81-7
Molecular Formula:C₁₂H₁₃F₂NO₃
Molecular Weight:257.237
Hs Code.:

Synonyms:2-(2,2-dimethylpropionylamino)-4,6-difluorobenzoic acid

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Chemical Property of 2-(2,2-dimethylpropionylamino)-4,6-difluorobenzoic acid

Chemical Property:

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Technology Process of 2-(2,2-dimethylpropionylamino)-4,6-difluorobenzoic acid

There total 1 articles about 2-(2,2-dimethylpropionylamino)-4,6-difluorobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 126674-77-9
2-amino-4,6-difluorobenzoic acid

: 3282-30-2
pivaloyl chloride

: 1609122-81-7
2-(2,2-dimethylpropionylamino)-4,6-difluorobenzoic acid

Guidance literature:: 2-amino-4,6-difluorobenzoic acid; pivaloyl chloride; With pyridine; In 1,4-dioxane; at 20 - 85 ℃; for 21h;

With water; sodium hydroxide; at 20 ℃; for 2h;

Reference yield:

: 1609122-81-7
2-(2,2-dimethylpropionylamino)-4,6-difluorobenzoic acid

: 100-51-6,185532-71-2
benzyl alcohol

: 1609122-80-6
2-benzyloxy-6-(2,2-dimethylpropionylamino)-4-fluorobenzoic acid

Guidance literature:: benzyl alcohol; With lithium tert-butoxide; In dimethyl sulfoxide; at 80 ℃; for 0.0833333h;

2-(2,2-dimethylpropionylamino)-4,6-difluorobenzoic acid; In dimethyl sulfoxide; at 80 ℃; for 20h; Inert atmosphere;

Reference yield:

: 1609122-81-7
2-(2,2-dimethylpropionylamino)-4,6-difluorobenzoic acid

: 1609122-57-7
5-[2-((Z)-3-diethylaminoprop-1-enyl)-4-fluorobenzenesulfonyl-amino]-7-fluoro-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylic acid

Guidance literature:: Multi-step reaction with 11 steps

1.1: lithium tert-butoxide / dimethyl sulfoxide / 0.08 h / 80 °C

1.2: 20 h / 80 °C / Inert atmosphere

2.1: diazomethyl-trimethyl-silane / toluene; diethyl ether / 2 h / 0 - 20 °C / Inert atmosphere

3.1: 20% palladium hydroxide-activated charcoal; hydrogen; acetic acid / ethyl acetate / 25 h / 20 °C / Inert atmosphere

4.1: potassium carbonate / toluene; acetone / 20 h / Reflux

5.1: bis[(trifluoromethanesulfonyl)imidate]-2-(dicyclohexyl(2’,6’-dimethoxybiphenyl))phosphine gold(I) / toluene / 3 h / 85 °C

6.1: sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride / water; dichloromethane / 2 h / 50 °C

7.1: sulfuric acid; methanol / 24 h / Reflux

7.2: 24 h / Reflux

8.1: zinc; ammonium chloride / 20 h / 85 °C / Inert atmosphere

9.1: pyridine / dichloromethane / 48 h / 20 °C

10.1: tri tert-butylphosphoniumtetrafluoroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / dimethyl sulfoxide; 1,4-dioxane / 3.25 h / 75 °C / Inert atmosphere

11.1: lithium hydroxide monohydrate; water / 1,4-dioxane / 20 h / 100 °C / Inert atmosphere

With pyridine; methanol; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium hydroxide monohydrate; sulfuric acid; bis[(trifluoromethanesulfonyl)imidate]-2-(dicyclohexyl(2’,6’-dimethoxybiphenyl))phosphine gold(I); 20% palladium hydroxide-activated charcoal; N-benzyl-N,N,N-triethylammonium chloride; water; hydrogen; potassium carbonate; ammonium chloride; acetic acid; sodium hydroxide; lithium tert-butoxide; tri tert-butylphosphoniumtetrafluoroborate; zinc; diazomethyl-trimethyl-silane; In 1,4-dioxane; diethyl ether; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; acetone; toluene;