(5-(6-bromo-[1,2,4]triazolo[4,3-a]pyridin-3-yl)-2,4-dihydroxyphenyl)(4-methylpiperazin-1-yl)methanone

Base Information

Chemical Name:(5-(6-bromo-[1,2,4]triazolo[4,3-a]pyridin-3-yl)-2,4-dihydroxyphenyl)(4-methylpiperazin-1-yl)methanone
CAS No.:1609699-55-9
Molecular Formula:C₁₈H₁₈BrN₅O₃
Molecular Weight:432.277
Hs Code.:

Synonyms:(5-(6-bromo-[1,2,4]triazolo[4,3-a]pyridin-3-yl)-2,4-dihydroxyphenyl)(4-methylpiperazin-1-yl)methanone

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Chemical Property of (5-(6-bromo-[1,2,4]triazolo[4,3-a]pyridin-3-yl)-2,4-dihydroxyphenyl)(4-methylpiperazin-1-yl)methanone

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Technology Process of (5-(6-bromo-[1,2,4]triazolo[4,3-a]pyridin-3-yl)-2,4-dihydroxyphenyl)(4-methylpiperazin-1-yl)methanone

There total 8 articles about (5-(6-bromo-[1,2,4]triazolo[4,3-a]pyridin-3-yl)-2,4-dihydroxyphenyl)(4-methylpiperazin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.3%

: 1609699-88-8
(5-(6-bromo-[1,2,4]triazolo[4,3-a]pyridin-3-yl)-2,4-dimethoxyphenyl)(4-methylpiperazin-1-yl)methanone

: 1609699-55-9
(5-(6-bromo-[1,2,4]triazolo[4,3-a]pyridin-3-yl)-2,4-dihydroxyphenyl)(4-methylpiperazin-1-yl)methanone

Guidance literature:: With boron tribromide; In dichloromethane; at -78 - 50 ℃; for 50h; Inert atmosphere;
DOI:10.1016/j.bmcl.2014.03.100

Reference yield:

: 2150-41-6
methyl 2, 4-dimethoxybenzoate

: 1609699-55-9
(5-(6-bromo-[1,2,4]triazolo[4,3-a]pyridin-3-yl)-2,4-dihydroxyphenyl)(4-methylpiperazin-1-yl)methanone

Guidance literature:: Multi-step reaction with 6 steps

1: titanium tetrachloride / dichloromethane / 0.5 h / 0 °C

2: ethanol / 2 h / Reflux

3: iodobenzene diacetic acid / dichloromethane; methanol / 20 °C

4: lithium hydroxide; water / methanol / 2 h / 80 °C

5: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

6: boron tribromide / dichloromethane / 50 h / -78 - 50 °C / Inert atmosphere

With iodobenzene diacetic acid; water; boron tribromide; titanium tetrachloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In methanol; ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2014.03.100

Reference yield:

: 1609699-52-6
methyl 5-((2-(5-bromopyridin-2-yl)hydrazono)methyl)-2,4-dimethoxybenzoate

: 1609699-55-9
(5-(6-bromo-[1,2,4]triazolo[4,3-a]pyridin-3-yl)-2,4-dihydroxyphenyl)(4-methylpiperazin-1-yl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1: iodobenzene diacetic acid / dichloromethane; methanol / 20 °C

2: lithium hydroxide; water / methanol / 2 h / 80 °C

3: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

4: boron tribromide / dichloromethane / 50 h / -78 - 50 °C / Inert atmosphere

With iodobenzene diacetic acid; water; boron tribromide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In methanol; dichloromethane;
DOI:10.1016/j.bmcl.2014.03.100