1-(2,6-dichlorophenyl)-3-(4-methoxyphenyl)methyl-5-bromo-7-methoxy-3,4-dihydro-2(1H)-quinazolinone

Base Information

• Chemical Name: 1-(2,6-dichlorophenyl)-3-(4-methoxyphenyl)methyl-5-bromo-7-methoxy-3,4-dihydro-2(1H)-quinazolinone
• CAS No.: 444663-78-9
• Molecular Formula: C₂₃H₁₉BrCl₂N₂O₃
• Molecular Weight: 522.225
• Mol file: 444663-78-9.mol

Synonyms:1-(2,6-dichlorophenyl)-3-(4-methoxyphenyl)methyl-5-bromo-7-methoxy-3,4-dihydro-2(1H)-quinazolinone

Chemical Property of 1-(2,6-dichlorophenyl)-3-(4-methoxyphenyl)methyl-5-bromo-7-methoxy-3,4-dihydro-2(1H)-quinazolinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2,6-dichlorophenyl)-3-(4-methoxyphenyl)methyl-5-bromo-7-methoxy-3,4-dihydro-2(1H)-quinazolinone

There total 5 articles about 1-(2,6-dichlorophenyl)-3-(4-methoxyphenyl)methyl-5-bromo-7-methoxy-3,4-dihydro-2(1H)-quinazolinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

copper(I) iodide (7681-65-4) + N-[(2,6-dibromo-4-methoxyphenyl)methyl]-N'-(2,6-dichlorophenyl)-N-[(4-methoxyphenyl)methyl]urea (444663-77-8) → 1-(2,6-dichlorophenyl)-3-(4-methoxyphenyl)methyl-5-bromo-7-methoxy-3,4-dihydro-2(1H)-quinazolinone (444663-78-9)

Guidance literature:

With ammonium hydroxide; potassium carbonate; In water; N,N-dimethyl-formamide;

Reference yield:

N-[(2,6-dibromo-4-methoxyphenyl)methyl]-N'-(2,6-dichlorophenyl)-N-[(4-methoxyphenyl)methyl]urea (444663-77-8) → 1-(2,6-dichlorophenyl)-3-(4-methoxyphenyl)methyl-5-bromo-7-methoxy-3,4-dihydro-2(1H)-quinazolinone (444663-78-9)

Guidance literature:

With copper(l) iodide; potassium carbonate; In N,N-dimethyl-formamide; at 150 ℃; for 0.25h;

DOI:10.1016/S0960-894X(02)00752-7

Reference yield:

2,6-dibromo-4-methoxytoluene (14542-71-3) → 1-(2,6-dichlorophenyl)-3-(4-methoxyphenyl)methyl-5-bromo-7-methoxy-3,4-dihydro-2(1H)-quinazolinone (444663-78-9)

Guidance literature:

Multi-step reaction with 4 steps

1: NBS; Bz₂O₂

2: CuI; K₂CO₃ / dimethylformamide / 0.25 h / 150 °C

With N-Bromosuccinimide; copper(l) iodide; potassium carbonate; dibenzoyl peroxide; In N,N-dimethyl-formamide; 4: Ullmann coupling;

DOI:10.1016/S0960-894X(02)00752-7

upstream raw materials:

N-[(2,6-dibromo-4-methoxyphenyl)methyl]-N'-(2,6-dichlorophenyl)-N-[(4-methoxyphenyl)methyl]urea

2,6-dibromo-4-methoxytoluene

1,3-dibromo-2-(bromomethyl)-5-methoxybenzene

(2,6-dibromo-4-methoxy-benzyl)-(4-methoxy-benzyl)-amine

Downstream raw materials:

1-(2,6-dichlorophenyl)-5-bromo-7-methoxy-3,4-dihydro-2(1H)-quinazolinone

1-(2,6-dichlorophenyl)-5-(2-chlorophenyl)-7-hydroxy-3,4-dihydro-2(1 H)-quinazolinone

1-(2,6-dichlorophenyl)-5-(2-chlorophenyl)-7-methoxy-3,4-dihydro-2(1H)-quinazolinone

1-(2,6-dichlorophenyl)-5-(2-chloro-4-fluorophenyl)-7-methoxy-3,4-dihydro-2(1H)-quinazolinone