1-phenyl-3-propoxy-1,2,3,4-tetrahydroquinoline-6-carbaldehyde-N-4-(3-carboxymethyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidenmethyl)phenyl-N-phenylhydrazone

Base Information

• Chemical Name: 1-phenyl-3-propoxy-1,2,3,4-tetrahydroquinoline-6-carbaldehyde-N-4-(3-carboxymethyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidenmethyl)phenyl-N-phenylhydrazone
• CAS No.: 1529853-63-1
• Molecular Formula: C₃₇H₃₄N₄O₄S₂
• Molecular Weight: 662.833
• Mol file: 1529853-63-1.mol

Synonyms:1-phenyl-3-propoxy-1,2,3,4-tetrahydroquinoline-6-carbaldehyde-N-4-(3-carboxymethyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidenmethyl)phenyl-N-phenylhydrazone

Chemical Property of 1-phenyl-3-propoxy-1,2,3,4-tetrahydroquinoline-6-carbaldehyde-N-4-(3-carboxymethyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidenmethyl)phenyl-N-phenylhydrazone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-phenyl-3-propoxy-1,2,3,4-tetrahydroquinoline-6-carbaldehyde-N-4-(3-carboxymethyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidenmethyl)phenyl-N-phenylhydrazone

There total 7 articles about 1-phenyl-3-propoxy-1,2,3,4-tetrahydroquinoline-6-carbaldehyde-N-4-(3-carboxymethyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidenmethyl)phenyl-N-phenylhydrazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

rhodanine 3-acetic acid (5718-83-2) + 1-phenyl-3-propoxy-1,2,3,4-tetrahydroquinoline-6-carbaldehyde-N-(4-formyl)phenyl-N-phenyl-hydrazone (1529853-62-0) → 1-phenyl-3-propoxy-1,2,3,4-tetrahydroquinoline-6-carbaldehyde-N-4-(3-carboxymethyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidenmethyl)phenyl-N-phenylhydrazone (1529853-63-1)

Guidance literature:

With ammonium acetate; acetic acid; for 2h; Reflux;

Reference yield:

1-phenyl-3-propoxy-1,2,3,4-tetrahydroquinoline-6-carbaldehyde N-phenylhydrazone (1529853-61-9) → 1-phenyl-3-propoxy-1,2,3,4-tetrahydroquinoline-6-carbaldehyde-N-4-(3-carboxymethyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidenmethyl)phenyl-N-phenylhydrazone (1529853-63-1)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 90 °C / Inert atmosphere

2: ammonium acetate / acetic acid / 2 h / 100 °C

With ammonium acetate; potassium carbonate; In acetic acid; N,N-dimethyl-formamide; 2: |Knoevenagel Condensation;

DOI:10.1016/j.dyepig.2014.01.010

Reference yield:

1-phenyl-3-propoxy-1,2,3,4-tetrahydroquinoline-6-carbaldehyde (1175004-74-6) → 1-phenyl-3-propoxy-1,2,3,4-tetrahydroquinoline-6-carbaldehyde-N-4-(3-carboxymethyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidenmethyl)phenyl-N-phenylhydrazone (1529853-63-1)

Guidance literature:

Multi-step reaction with 3 steps

1: isopropyl alcohol / 3 h / 85 °C

2: potassium carbonate / N,N-dimethyl-formamide / 3 h / 90 °C / Inert atmosphere

3: ammonium acetate / acetic acid / 2 h / 100 °C

With ammonium acetate; potassium carbonate; In acetic acid; N,N-dimethyl-formamide; isopropyl alcohol; 3: |Knoevenagel Condensation;

DOI:10.1016/j.dyepig.2014.01.010

upstream raw materials:

acetic acid 1-phenyl-1,2,3,4-tetrahydro-quinolin-3-yl ester

3-acetyl-1-phenyl-1,2,3,4-tetrahydroquinoline-6-carbaldehyde

rhodanine 3-acetic acid

1-phenyl-3-propoxy-1,2,3,4-tetrahydroquinoline-6-carbaldehyde-N-(4-formyl)phenyl-N-phenyl-hydrazone