10.1002/ardp.201100082
The research focuses on the synthesis and evaluation of a series of indolin-2-one derivatives containing the 4-thiazolidinone moiety (5a–5p) for their anticancer activity. The compounds were synthesized using a series of chemical reactions involving rhodanine-3-acetic acid, various benzaldehydes, and indolin-2-ones. The synthesized compounds were evaluated for their cytotoxicity against three human cancer cell lines (HT-29, H460, and MDA-MB-231) using the MTT assay. Promising compounds were further tested against a normal cell line (WI-38). The results showed that some of the synthesized compounds exhibited significant cytotoxicity, with compound 5h showing particularly high potency against HT-29 and H460 cancer cell lines. The study suggests that the combination of indolin-2-one and 5-benzylidene-4-thiazolidinone moieties enhances anticancer activity, and that specific substitutions on the indolin-2-one ring can further improve cytotoxicity and selectivity.
10.1016/j.bmcl.2012.01.052
The research is focused on the synthesis and evaluation of a new class of 2-(trifluoromethyl)-6-arylimidazo[2,1-b][1,3,4]thiadiazole derivatives as potential antitubercular agents. The researchers synthesized these compounds using both conventional and microwave-assisted methods, and evaluated their in vitro antitubercular activity against M. tuberculosis H37Rv. The chemicals that played a role in the research include 5-(trifluoromethyl)-1,3,4-thiadiazol-2-amine, various substituted α-haloaryl ketones, thiazolidine-2,4-dione, 2-thioxothiazolidin-4-one (rhodanine), and 2-(4-oxo-2-thioxothiazolidin-3-yl)acetic acid (rhodanine acetic acid). The synthesized compounds were characterized by IR, NMR, mass spectra, and elemental analysis. The study found that several compounds exhibited good antitubercular activity, with some showing promising potential as lead scaffolds for the development of new anti-TB agents.
10.1016/j.tet.2006.12.082
The research focuses on the molecular engineering of organic dyes containing the N-aryl carbazole moiety for application in solar cells, specifically dye-sensitized solar cells (DSSCs). The purpose of this study was to design and synthesize novel organic dyes that could overcome the limitations of low conversion efficiency and operational stability often associated with organic dyes in DSSCs, as compared to metal-based complexes. The researchers aimed to develop alternative, highly efficient organic dyes that could potentially rival the performance of ruthenium complexes, which are known for their high efficiency but are prohibitively expensive. In the process, various chemicals were used, including 2-iodo-9,9-dimethylfluorene, 3-iodocarbazole, 1-bromo-4-(2,2-diphenylvinyl)benzene, and (2-thienylmethyl)triphenylphosphonium bromide, which were synthesized using modified procedures from previous references. Other chemicals involved in the synthesis steps included tributyl(thiophen-2-yl)stannane, Pd(PPh3)4, copper bronze, potassium carbonate, 18-crown-6, n-butyl lithium, cyanoacetic acid, piperidine, rhodanine-3-acetic acid, and ammonium acetate, among others. These chemicals were utilized in a series of reactions such as coupling, lithiation, and condensation to synthesize the target dyes, which were then tested for their photovoltaic performance in DSSCs.
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