C₂₅H₂₄ClN₇O₄

Base Information

• Chemical Name: C₂₅H₂₄ClN₇O₄
• CAS No.: 1392514-39-4
• Molecular Formula: C₂₅H₂₄ClN₇O₄
• Molecular Weight: 521.963
• Mol file: 1392514-39-4.mol

Synonyms:C₂₅H₂₄ClN₇O₄

Chemical Property of C₂₅H₂₄ClN₇O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₅H₂₄ClN₇O₄

There total 16 articles about C₂₅H₂₄ClN₇O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

C25H24ClN7O4*(x)ClH → C25H24ClN7O4 (1392514-39-4)

Guidance literature:

In dichloromethane; water; at 20 - 25 ℃; Industry scale; Inert atmosphere;

Reference yield:

2-amino-5-bromo-4-methylpyridine (98198-48-2) → C25H24ClN7O4 (1392514-39-4)

Guidance literature:

Multi-step reaction with 12 steps

1.1: sulfuric acid; nitric acid / water / 7 h / 25 - 33 °C / Large scale

2.1: tert.-butylnitrite; sulfuric acid / 9.5 h / 20 - 43 °C / Large scale

3.1: N,N-dimethyl-formamide / 80 - 100 °C / Large scale

4.1: methanol; propanoic acid methyl ester; copper(l) iodide / tetrahydrofuran / 21 h / 30 - 72 °C / Large scale

5.1: 5%-palladium/activated carbon; hydrogen / ethyl acetate / 24 h / 25 - 35 °C / 1275.13 - 1500.15 Torr / Autoclave; Large scale

5.2: 10 - 30 °C / Large scale

6.1: trichlorophosphate / neat (no solvent) / 15 h / 40 - 102 °C / Large scale

7.1: methanol / toluene / 8 h / 45 - 55 °C / Large scale

8.1: Methyl isobutyl carbinol / 76 h / 130 - 145 °C / Large scale

9.1: isopropylmagnesium chloride; pyridine / 2-methyltetrahydrofuran / -25 - -10 °C / Large scale

9.2: 3 h / -25 - -10 °C / Large scale

10.1: N,N,N',N',N-pentamethylguanidine / 1-methyl-pyrrolidin-2-one

11.1: tetrabutoxytitanium / 2-methyltetrahydrofuran / Reflux

12.1: chlorine / dichloromethane / 3 h / -2 - 0 °C / Large scale

With pyridine; tetrabutoxytitanium; methanol; Methyl isobutyl carbinol; copper(l) iodide; tert.-butylnitrite; propanoic acid methyl ester; sulfuric acid; 5%-palladium/activated carbon; hydrogen; isopropylmagnesium chloride; nitric acid; chlorine; trichlorophosphate; N,N,N',N',N-pentamethylguanidine; In tetrahydrofuran; 2-methyltetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene; 2.1: |Sandmeyer Reaction / 3.1: |Leimgruber-Batcho Indole Synthesis / 5.1: |Leimgruber-Batcho Indole Synthesis;

DOI:10.1021/acs.oprd.7b00134

Reference yield:

N-(5-bromo-4-methylpyridin-2-yl)acetamide (142404-82-8) → C25H24ClN7O4 (1392514-39-4)

Guidance literature:

Multi-step reaction with 12 steps

1.1: nitric acid; sulfuric acid

2.1: chloro-trimethyl-silane; sodium nitrite

4.1: sodium methylate; ammonium chloride / copper(l) iodide / tetrahydrofuran

5.1: hydrogen / 1% Pd on activated carbon / ethyl acetate

6.1: trichlorophosphate

7.1: 4-Me-2-pentanol

8.1: isopropylmagnesium chloride / tetrahydrofuran

9.1: N,N,N',N'-tetramethylguanidine / 1-methyl-pyrrolidin-2-one / 2 h / 20 °C / Industry scale; Inert atmosphere

9.2: 18.03 h / 20 °C / Industry scale

10.1: tetrabutoxytitanium / 2-methyltetrahydrofuran / 3 h / Inert atmosphere; Reflux

11.1: chlorine / dichloromethane / -3 - 3 °C / Inert atmosphere; Industry scale

12.1: dichloromethane; water / 20 - 25 °C / Industry scale; Inert atmosphere

With tetrabutoxytitanium; chloro-trimethyl-silane; sulfuric acid; hydrogen; isopropylmagnesium chloride; nitric acid; sodium methylate; chlorine; ammonium chloride; sodium nitrite; trichlorophosphate; N,N,N',N'-tetramethylguanidine; copper(l) iodide; 1% Pd on activated carbon; In tetrahydrofuran; 2-methyltetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; 4-Me-2-pentanol; water; ethyl acetate;

upstream raw materials:

N-(5-bromo-4-methylpyridin-2-yl)acetamide

2-amino-3-nitro-4-methyl-5-bromopyridine

4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridine

methyl 2-(4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-oxoacetate

Downstream raw materials:

1,3-dihydroxy-2-(hydroxymethyl)propan-2-aminium (3-(2-(4-benzoylpiperazin-1-yl)-2-oxoacetyl)-4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-1-yl)methyl hydrogen phosphate