N'-(2-tert-butoxycarbonylamino-3-phenyl-propionyl)-N-(2-carbamoyl-ethyl)-hydrazinecarboxylic acid 2,2,2-trichloro-ethyl ester

Base Information

• Chemical Name: N'-(2-tert-butoxycarbonylamino-3-phenyl-propionyl)-N-(2-carbamoyl-ethyl)-hydrazinecarboxylic acid 2,2,2-trichloro-ethyl ester
• CAS No.: 222853-58-9
• Molecular Formula: C₂₀H₂₇Cl₃N₄O₆
• Molecular Weight: 525.817

Synonyms:N'-(2-tert-butoxycarbonylamino-3-phenyl-propionyl)-N-(2-carbamoyl-ethyl)-hydrazinecarboxylic acid 2,2,2-trichloro-ethyl ester

Chemical Property of N'-(2-tert-butoxycarbonylamino-3-phenyl-propionyl)-N-(2-carbamoyl-ethyl)-hydrazinecarboxylic acid 2,2,2-trichloro-ethyl ester

Chemical Property:

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Technology Process of N'-(2-tert-butoxycarbonylamino-3-phenyl-propionyl)-N-(2-carbamoyl-ethyl)-hydrazinecarboxylic acid 2,2,2-trichloro-ethyl ester

There total 2 articles about N'-(2-tert-butoxycarbonylamino-3-phenyl-propionyl)-N-(2-carbamoyl-ethyl)-hydrazinecarboxylic acid 2,2,2-trichloro-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

3-propanamide (133382-98-6) + 2,2,2-Trichloroethyl chloroformate (17341-93-4) → N'-(2-tert-butoxycarbonylamino-3-phenyl-propionyl)-N-(2-carbamoyl-ethyl)-hydrazinecarboxylic acid 2,2,2-trichloro-ethyl ester (222853-58-9)

Guidance literature:

With triethylamine; In methanol;

DOI:10.1016/S0960-894X(99)00049-9

Reference yield:

(S)-tert-butyl (1-hydrazinyl-1-oxo-3-phenylpropan-2-yl)carbamate (30189-48-1) → N'-(2-tert-butoxycarbonylamino-3-phenyl-propionyl)-N-(2-carbamoyl-ethyl)-hydrazinecarboxylic acid 2,2,2-trichloro-ethyl ester (222853-58-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 40 percent / dimethylformamide / 36 h / 110 °C

2: 68 percent / Et₃N / methanol

With triethylamine; In methanol; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(99)00049-9

Reference yield:

N'-(2-tert-butoxycarbonylamino-3-phenyl-propionyl)-N-(2-carbamoyl-ethyl)-hydrazinecarboxylic acid 2,2,2-trichloro-ethyl ester (222853-58-9) → N'-(2-amino-3-phenyl-propionyl)-N-(2-carbamoyl-ethyl)-hydrazinecarboxylic acid 2,2,2-trichloro-ethyl ester

Guidance literature:

With trifluoroacetic acid; In dichloromethane;

DOI:10.1016/S0960-894X(99)00049-9

upstream raw materials:

3-propanamide

2,2,2-Trichloroethyl chloroformate

(S)-tert-butyl (1-hydrazinyl-1-oxo-3-phenylpropan-2-yl)carbamate

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