6-chloro-1-(2-nitrophenyl)-1'-(phenoxycarbonyl)spiro

Base Information

Chemical Name:6-chloro-1-(2-nitrophenyl)-1'-(phenoxycarbonyl)spiro
CAS No.:75391-89-8
Molecular Formula:C₂₅H₂₂ClN₃O₄
Molecular Weight:463.92
Hs Code.:

6-chloro-1-(2-nitrophenyl)-1'-(phenoxycarbonyl)spiro<indoline-3,4'-piperidine>

Synonyms:6-chloro-1-(2-nitrophenyl)-1'-(phenoxycarbonyl)spiro

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Chemical Property of 6-chloro-1-(2-nitrophenyl)-1'-(phenoxycarbonyl)spiro

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Technology Process of 6-chloro-1-(2-nitrophenyl)-1'-(phenoxycarbonyl)spiro

There total 5 articles about 6-chloro-1-(2-nitrophenyl)-1'-(phenoxycarbonyl)spiro which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 75391-96-7
6-chloro-1'-methyl-1-(2-nitrophenyl)spiro[indoline-3,4'-piperidine]

: 1885-14-9
phenyl chloroformate

: 75391-89-8
6-chloro-1-(2-nitrophenyl)-1'-(phenoxycarbonyl)spiro

Guidance literature:: In dichloromethane; for 16h; Ambient temperature;
DOI:10.1021/jm00361a009

Reference yield:

: 75279-53-7
2-(4-chloro-2-fluoro-phenyl)acetonitrile

: 75391-89-8
6-chloro-1-(2-nitrophenyl)-1'-(phenoxycarbonyl)spiro

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaH / 1.) DMSO, 30 min, 2.) DMSO, 75 deg C, 4 h

2: 93 percent / lithium triethoxyaluminum hydride, lithium aluminum hydride / 1,2-dimethoxy-ethane / 72 h / Heating

3: 84 percent / 5 h / 170 - 175 °C

4: 76 percent / CH₂Cl₂ / 16 h / Ambient temperature

With lithium aluminium tetrahydride; sodium hydride; lithium triethoxyaluminum hydride; In 1,2-dimethoxyethane; dichloromethane;
DOI:10.1021/jm00361a009

Reference yield:

: 55-86-7
mechlorethamine hydrochloride

: 75391-89-8
6-chloro-1-(2-nitrophenyl)-1'-(phenoxycarbonyl)spiro

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaH / 1.) DMSO, 30 min, 2.) DMSO, 75 deg C, 4 h

2: 93 percent / lithium triethoxyaluminum hydride, lithium aluminum hydride / 1,2-dimethoxy-ethane / 72 h / Heating

3: 84 percent / 5 h / 170 - 175 °C

4: 76 percent / CH₂Cl₂ / 16 h / Ambient temperature

With lithium aluminium tetrahydride; sodium hydride; lithium triethoxyaluminum hydride; In 1,2-dimethoxyethane; dichloromethane;
DOI:10.1021/jm00361a009