spiro[5'.3]oxindolespiro[6'.16]-7'-(phenyl)tetrahydro-1H-pyrrolo[1',2'-c][1',3']thiazoloestrone

Base Information

• Chemical Name: spiro[5'.3]oxindolespiro[6'.16]-7'-(phenyl)tetrahydro-1H-pyrrolo[1',2'-c][1',3']thiazoloestrone
• CAS No.: 1585173-27-8
• Molecular Formula: C₃₆H₃₆N₂O₃S
• Molecular Weight: 576.759
• Mol file: 1585173-27-8.mol

Synonyms:spiro[5'.3]oxindolespiro[6'.16]-7'-(phenyl)tetrahydro-1H-pyrrolo[1',2'-c][1',3']thiazoloestrone

Chemical Property of spiro[5'.3]oxindolespiro[6'.16]-7'-(phenyl)tetrahydro-1H-pyrrolo[1',2'-c][1',3']thiazoloestrone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of spiro[5'.3]oxindolespiro[6'.16]-7'-(phenyl)tetrahydro-1H-pyrrolo[1',2'-c][1',3']thiazoloestrone

There total 3 articles about spiro[5'.3]oxindolespiro[6'.16]-7'-(phenyl)tetrahydro-1H-pyrrolo[1',2'-c][1',3']thiazoloestrone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

(E)-16-benzyliden-3β-hydroxyestra-1,3,5(10)-trien-17-one (879880-13-4) + indole-2,3-dione (91-56-5,1186480-61-4,84788-92-1) + (RS)-4-thiazolidinecarboxylic acid (444-27-9,19291-02-2,34592-47-7,45521-09-3,2756-91-4,6070-92-4,60731-25-1) → spiro[5'.3]oxindolespiro[6'.16]-7'-(phenyl)tetrahydro-1H-pyrrolo[1',2'-c][1',3']thiazoloestrone (1585173-27-8)

Guidance literature:

In isopropyl alcohol; for 3h; stereoselective reaction; Reflux;

DOI:10.1016/j.steroids.2014.01.003

Reference yield:

benzaldehyde (100-52-7) → spiro[5'.3]oxindolespiro[6'.16]-7'-(phenyl)tetrahydro-1H-pyrrolo[1',2'-c][1',3']thiazoloestrone (1585173-27-8)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide / ethanol / 5 h / Reflux

2: isopropyl alcohol / 3 h / Reflux

With potassium hydroxide; In ethanol; isopropyl alcohol;

DOI:10.1016/j.steroids.2014.01.003

Reference yield:

Estrone (53-16-7) → spiro[5'.3]oxindolespiro[6'.16]-7'-(phenyl)tetrahydro-1H-pyrrolo[1',2'-c][1',3']thiazoloestrone (1585173-27-8)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide / ethanol / 5 h / Reflux

2: isopropyl alcohol / 3 h / Reflux

With potassium hydroxide; In ethanol; isopropyl alcohol;

DOI:10.1016/j.steroids.2014.01.003

upstream raw materials:

Estrone

(E)-16-benzyliden-3β-hydroxyestra-1,3,5(10)-trien-17-one

indole-2,3-dione

(RS)-4-thiazolidinecarboxylic acid