1-[4-(3-{4-[bis(4-fluorophenyl)(hydroxy)methyl]piperidin-1-yl}propoxy)phenyl]-2-methylpropan-1-one ethanedioate (1:1)

Base Information

Chemical Name:1-[4-(3-{4-[bis(4-fluorophenyl)(hydroxy)methyl]piperidin-1-yl}propoxy)phenyl]-2-methylpropan-1-one ethanedioate (1:1)
CAS No.:117023-62-8
Molecular Formula:C33H37F2NO7
Molecular Weight:597.6462
Hs Code.:
Mol file:117023-62-8.mol

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-[4-(3-{4-[bis(4-fluorophenyl)(hydroxy)methyl]piperidin-1-yl}propoxy)phenyl]-2-methylpropan-1-one ethanedioate (1:1)

Chemical Property:

Vapor Pressure:2.76E-17mmHg at 25°C
Boiling Point:640.6°C at 760 mmHg
Flash Point:341.2°C
PSA：124.37000
LogP:5.31400

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-[4-(3-{4-[bis(4-fluorophenyl)(hydroxy)methyl]piperidin-1-yl}propoxy)phenyl]-2-methylpropan-1-one ethanedioate (1:1)

There total 4 articles about 1-[4-(3-{4-[bis(4-fluorophenyl)(hydroxy)methyl]piperidin-1-yl}propoxy)phenyl]-2-methylpropan-1-one ethanedioate (1:1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 144-62-7,97993-78-7
oxalic acid

: 60284-98-2
1,1-bis(4-fluorophenyl)-1-(4-piperidinyl)methanol

: 117022-48-7
1-[4-(3-chloropropoxy)phenyl]-2-methyl-1-propanone

: 117023-62-8
1-[4-(3-{4-[Bis-(4-fluoro-phenyl)-hydroxy-methyl]-piperidin-1-yl}-propoxy)-phenyl]-2-methyl-propan-1-one; compound with oxalic acid

Guidance literature:: With sodium carbonate; potassium iodide; 1) n-butanol, reflux;
DOI:10.1021/jm00121a022

Reference yield:

: 24228-40-8
N-benzyl isonipecotic acid ethyl ester

: 117023-62-8
1-[4-(3-{4-[Bis-(4-fluoro-phenyl)-hydroxy-methyl]-piperidin-1-yl}-propoxy)-phenyl]-2-methyl-propan-1-one; compound with oxalic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 1) Mg / 1) THF, reflux, 15 min.; 2) THF, room temperature, overnight

2: 92 percent / H₂ / 5percent Pd/C / ethanol / 48 h / 70 °C / 2585.7 Torr

3: 73 percent / 1) Na₂CO₃, KI / 1) n-butanol, reflux

With hydrogen; sodium carbonate; magnesium; potassium iodide; palladium on activated charcoal; In ethanol;
DOI:10.1021/jm00121a022

Reference yield:

: 460-00-4
1-Bromo-4-fluorobenzene

: 117023-62-8
1-[4-(3-{4-[Bis-(4-fluoro-phenyl)-hydroxy-methyl]-piperidin-1-yl}-propoxy)-phenyl]-2-methyl-propan-1-one; compound with oxalic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 1) Mg / 1) THF, reflux, 15 min.; 2) THF, room temperature, overnight

2: 92 percent / H₂ / 5percent Pd/C / ethanol / 48 h / 70 °C / 2585.7 Torr

3: 73 percent / 1) Na₂CO₃, KI / 1) n-butanol, reflux

With hydrogen; sodium carbonate; magnesium; potassium iodide; palladium on activated charcoal; In ethanol;
DOI:10.1021/jm00121a022