(R)-N-(3,5-dichlorophenyl)-2-[3-(2,2-dimethoxyethyl)ureido]-2-methyl-3-(4-trifluoromethoxyphenyl)propionamide

Base Information

Chemical Name:(R)-N-(3,5-dichlorophenyl)-2-[3-(2,2-dimethoxyethyl)ureido]-2-methyl-3-(4-trifluoromethoxyphenyl)propionamide
CAS No.:944580-11-4
Molecular Formula:C₂₂H₂₄Cl₂F₃N₃O₅
Molecular Weight:538.351
Hs Code.:

Synonyms:(R)-N-(3,5-dichlorophenyl)-2-[3-(2,2-dimethoxyethyl)ureido]-2-methyl-3-(4-trifluoromethoxyphenyl)propionamide

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Chemical Property of (R)-N-(3,5-dichlorophenyl)-2-[3-(2,2-dimethoxyethyl)ureido]-2-methyl-3-(4-trifluoromethoxyphenyl)propionamide

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Technology Process of (R)-N-(3,5-dichlorophenyl)-2-[3-(2,2-dimethoxyethyl)ureido]-2-methyl-3-(4-trifluoromethoxyphenyl)propionamide

There total 8 articles about (R)-N-(3,5-dichlorophenyl)-2-[3-(2,2-dimethoxyethyl)ureido]-2-methyl-3-(4-trifluoromethoxyphenyl)propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 875210-74-5
(2,2-dimethoxy-ethyl)-carbamic acid phenyl ester

: 1175561-69-9
(R)-2-amino-3-(4-trifluoromethoxyphenyl)-N-(3,5-dichlorophenyl)-2-methylpropionamide p-toluenesulfonic acid salt

: 944580-11-4
(R)-N-(3,5-dichlorophenyl)-2-[3-(2,2-dimethoxyethyl)ureido]-2-methyl-3-(4-trifluoromethoxyphenyl)propionamide

Guidance literature:: With triethylamine; In tert-butyl methyl ether; dimethyl sulfoxide; at 60 ℃; for 3h;
DOI:10.1021/ol101960x

Reference yield:

: 626-43-7
3,5-Dichloroaniline

: 944580-11-4
(R)-N-(3,5-dichlorophenyl)-2-[3-(2,2-dimethoxyethyl)ureido]-2-methyl-3-(4-trifluoromethoxyphenyl)propionamide

Guidance literature:: Multi-step reaction with 7 steps

2.1: toluene

3.1: water; sodium hydroxide / ethyl acetate / 0.5 h

3.2: 10.5 h / 17 - 23 °C / Reflux

3.3: 12 h / 50 °C

4.1: 3 h / 0 - 20 °C

5.1: 1.5 h / 0 - 5 °C

6.1: potassium hydroxide / isopropyl alcohol / 1 h / 60 °C

6.2: 3 h / 60 °C

7.1: 3 h / 60 °C

With water; potassium hydroxide; sodium hydroxide; In ethyl acetate; isopropyl alcohol; toluene;
DOI:10.1021/op200175t

Reference yield:

: 1246745-48-1
(2R,5R)-5-(4-trifluoromethoxybenzyl)-3-(3,5-dichlorophenyl)-2-isopropyl-5-methyl-1-(2,2,2-trifluoroacetyl)-imidazolidin-4-one

: 944580-11-4
(R)-N-(3,5-dichlorophenyl)-2-[3-(2,2-dimethoxyethyl)ureido]-2-methyl-3-(4-trifluoromethoxyphenyl)propionamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium hydroxide / isopropyl alcohol / 1 h / 60 °C

1.2: 3 h / 60 °C

2.1: 3 h / 60 °C

With potassium hydroxide; In isopropyl alcohol;
DOI:10.1021/op200175t